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Cancer Vaccine
Recombinant DNA + Adenovirus Vaccine for Non-Small Cell Lung Cancer
Phase 1
Waitlist Available
Research Sponsored by Corixa Corporation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Histologically and surgically confirmed diagnosis and stage of IB, IIA, or IIB non-small cell lung cancer (NSCLC) according to the Revised International System for Staging Lung Cancer
Chest X-ray and physical examination showing no active disease
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Study Summary
This trial is testing a new vaccine for early stage non-small cell lung cancer. The vaccine consists of two doses of recombinant DNA, followed by two doses of recombinant adenovirus. The trial will evaluate the safety and effectiveness of the vaccine.
Who is the study for?
This trial is for adults with early stage non-small cell lung cancer who've had surgery to remove it between 4 weeks and 3 years ago. They must have no current signs of cancer, be in good physical condition, and have normal blood counts and organ function. Women over 60 or not able to become pregnant can join; men must use contraception.Check my eligibility
What is being tested?
The study tests a new vaccine regimen using recombinant DNA and adenovirus that targets the L523S protein in lung cancer patients. It involves escalating doses through three patient groups to assess safety and how well the body responds (immunogenicity).See study design
What are the potential side effects?
Potential side effects may include typical reactions related to vaccines such as soreness at injection site, fever, fatigue, allergic reactions, or more serious immune responses if the body reacts against its own tissues.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My lung cancer is confirmed to be stage IB, IIA, or IIB.
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My recent chest X-ray and physical exam showed no signs of active disease.
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My kidney function is within the normal range.
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My liver function tests are within normal ranges.
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I am fully active or can carry out light work.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
Find a Location
Who is running the clinical trial?
Corixa CorporationLead Sponsor
9 Previous Clinical Trials
581 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- My cancer's stage is not clearly defined.I have had radiation therapy before or after surgery.I haven't taken systemic or inhaled steroids or immunosuppressants in the last 4 weeks.My lung cancer is confirmed to be stage IB, IIA, or IIB.I had lung cancer surgery between 4 weeks and 3 years ago.My recent chest X-ray and physical exam showed no signs of active disease.I have had cancer before, but it was either non-melanoma skin cancer, superficial bladder cancer, or early-stage cervical cancer that was treated successfully.I do not have severe health issues that could make new cancer treatments too risky for me.I have received treatments like immunotherapy for my cancer.My kidney function is within the normal range.My liver function tests are within normal ranges.I am a woman over 60, have not had periods for 5+ years, or cannot have children due to surgery.I had chemotherapy as a preventive treatment less than 8 weeks ago.I am fully active or can carry out light work.I have an active autoimmune disease like lupus or rheumatoid arthritis.I haven't had any vaccines in the last 2 weeks.I do not have a severe lung infection, emphysema, or significantly reduced lung function.I have had bleeding in my stools or diarrhea in the last 4 weeks.I have tested positive for hepatitis C or B.I have or had a paraneoplastic syndrome.I have taken antibiotics within the last 2 weeks.I have received an organ transplant from another person.I am a man who can father a child and will use contraception for 6 months after joining.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Research Study Groups:
This trial has the following groups:Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How extensive is the scope of this trial in terms of its geographical reach?
"Currently, prospective patients can join the trial at five different medical facilities. These include Cancer Centers of Florida in Ocoee, Mary Crowley Medical Research Clinic in Dallas and Swedish Cancer Institute in Seattle among others."
Answered by AI
What level of risk should patients expect when undergoing this procedure?
"Due to the limited data regarding safety and efficacy, our team estimates this treatment's security rating on a scale from 1-3 as a lowly score of 1."
Answered by AI
Are there still opportunities for participants in this research study?
"According to clinicaltrials.gov, this investigation has been closed since December 5th 2006 and is no longer recruiting patients. Nevertheless, 2045 other trials are open for enrollment at the present time."
Answered by AI
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