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S-217622: Group C for Liver Disease

Phase 1
Waitlist Available
Research Sponsored by Shionogi
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0 (predose) up to 336 hours postdose on day 1 to day 15
Awards & highlights

Study Summary

This trial is testing a new drug to see how well it works in people with mild and moderate liver problems, compared to people with normal liver function.

Eligible Conditions
  • Liver Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0 (predose) up to 336 hours postdose on day 1 to day 15
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0 (predose) up to 336 hours postdose on day 1 to day 15 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Apparent Total Clearance (CL/F) of S-217622
Apparent Volume of Distribution (Vz/F) of S-217622
Area Under the Plasma Concentration-Time Curve (AUC) of S-217622
+8 more
Secondary outcome measures
Number of Participants with Treatment-Emergent Adverse Events

Trial Design

3Treatment groups
Experimental Treatment
Group I: S-217622: Group CExperimental Treatment1 Intervention
Participants with normal hepatic function will receive a single dose of S-217622 on Day 1, in a fasted state.
Group II: S-217622: Group BExperimental Treatment1 Intervention
Participants with moderate hepatic impairment will receive a single dose of S-217622 on Day 1, in a fasted state.
Group III: S-217622: Group AExperimental Treatment1 Intervention
Participants with mild hepatic impairment will receive a single dose of S-217622 on Day 1, in a fasted state.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
S-217622
2022
Completed Phase 1
~60

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

ShionogiLead Sponsor
116 Previous Clinical Trials
41,461 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
A Study to Assess S-217622 in Participants With Mild and Moderate Hepatic Impairment and Healthy Control Participants
2022. "A Study to Assess S-217622 in Participants With Mild and Moderate Hepatic Impairment and Healthy Control Participants". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05409911.
~10 spots leftby Apr 2025
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