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Peritoneal Resuscitation for Liver Disease

Phase 1
Waitlist Available
Led By Hunter B Moore, M.D., P.hD.
Research Sponsored by University of Colorado, Denver
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adult liver transplant recipients ≥18 y/o
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7-30 days postoperatively
Awards & highlights

Study Summary

This trial is assessing the safety of using a dextrose solution to improve blood flow in high-risk liver transplant patients. The goal is to see if this method is as effective and safe as it has been in other surgical patients.

Eligible Conditions
  • End Stage Liver Disease
  • Acute Kidney Injury
  • Obesity

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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Adults who have had a liver transplant and are 18 years old or older.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7-30 days postoperatively
This trial's timeline: 3 weeks for screening, Varies for treatment, and 7-30 days postoperatively for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percent of patients that complete DPR infusion without reaching stopping criteria
Secondary outcome measures
Abdominal compartment syndrome requiring reoperation
Duration of insulin infusion post-operatively
Hourly urine output for first 24 hours
+11 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Direct Peritoneal Resuscitation (DPR) GroupExperimental Treatment1 Intervention
At the time of abdominal closure and determination that the patient will either go to extended stay or the intensive care unit, three drains will be placed per standard of care. An additional 19 French drain will be placed at the ligament of Treitz at the base of the mesentery. Following abdominal closure DPR will be initiated with commercially available 2.5% glucose-based peritoneal dialysis solution at a rate of 1.5 cc/kg/hr based on previously reported therapy in trauma. Drains will be connected to continuous wall suction. This infusion will continue for the duration the patients stay in extended stay (8 hours) if they are deemed eligible for hospital ward admission, or for 24 hours if requiring ICU care. These patients will then be observed for their hospital course and monitored for outcomes listed above.

Find a Location

Who is running the clinical trial?

University of Colorado, DenverLead Sponsor
1,726 Previous Clinical Trials
2,141,661 Total Patients Enrolled
Hunter B Moore, M.D., P.hD.Principal InvestigatorUniversity of Colorado School of Medicine

Media Library

Direct Peritoneal Resuscitation (Other) Clinical Trial Eligibility Overview. Trial Name: NCT05195125 — Phase 1
Liver Disease Research Study Groups: Direct Peritoneal Resuscitation (DPR) Group
Liver Disease Clinical Trial 2023: Direct Peritoneal Resuscitation Highlights & Side Effects. Trial Name: NCT05195125 — Phase 1
Direct Peritoneal Resuscitation (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05195125 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the recruitment process for this experiment still open?

"Affirmative, clinicaltrials.gov provides evidence that this medical trial is still searching for participants; it was initially advertised on February 1st 2022 and recently updated the same day. 15 people need to be recruited from one single site."

Answered by AI

What adverse effects could result from Direct Peritoneal Resuscitation?

"Our team assigned Direct Peritoneal Resuscitation a score of 1 as it is currently undergoing Phase 1 testing, meaning there is only limited evidence regarding safety and efficacy."

Answered by AI

What is the current capacity of this clinical trial?

"Affirmative. According to information hosted on clinicaltrials.gov, this research is currently attempting to recruit participants as of February 1st 2022 and was last updated that same day. 15 individuals are needed at a single site for the trial."

Answered by AI
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~5 spots leftby Mar 2025