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Monoclonal Antibodies

VIP152 for Chronic Lymphocytic Leukemia

Phase 1
Waitlist Available
Research Sponsored by Vincerx Pharma, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 3 years
Awards & highlights

Study Summary

This trial will test the safety and effectiveness of VIP152 in patients with CLL or Richter Syndrome.

Eligible Conditions
  • Chronic Lymphocytic Leukemia
  • Non-Hodgkin's Lymphoma
  • Richter Syndrome
  • MYC Amplification
  • MYC Overexpression
  • MYC Translocation

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 3 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Safety and Tolerability
Secondary outcome measures
Assessment of pharmacokinetics (PK) of VIP152
Duration of Response
Overall Response Rate
+2 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: VIP152 in combination with BTKiExperimental Treatment2 Interventions
Investigating VIP152 in combination with a BTKi in patients with CLL
Group II: Monotherapy of VIP152Experimental Treatment1 Intervention
Investigating VIP152 in a monotherapy cohort in patients with high-risk CLL and Richter Syndrome

Find a Location

Who is running the clinical trial?

Vincerx Pharma, Inc.Lead Sponsor
3 Previous Clinical Trials
170 Total Patients Enrolled
Vincerx Study DirectorStudy DirectorVincerx Pharma, Inc.
3 Previous Clinical Trials
170 Total Patients Enrolled

Media Library

VIP152 (Monoclonal Antibodies) Clinical Trial Eligibility Overview. Trial Name: NCT04978779 — Phase 1
Chronic Lymphocytic Leukemia Research Study Groups: Monotherapy of VIP152, VIP152 in combination with BTKi
Chronic Lymphocytic Leukemia Clinical Trial 2023: VIP152 Highlights & Side Effects. Trial Name: NCT04978779 — Phase 1
VIP152 (Monoclonal Antibodies) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04978779 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has VIP152 been given the regulatory green light by the Food and Drug Administration?

"Data collected thus far suggests that VIP152 is relatively safe, subsequently earning it a score of 1. As this is only the first phase in testing its efficacy and safety, additional research needs to be conducted."

Answered by AI

Are there a number of medical facilities conducting this research program in the city?

"Currently, 4 clinical trial sites are enrolling patients for this medical study. Locations include Seattle, Columbus and Cincinnati as well as one other location. To reduce the need to travel extensively, it is best to select a site close by when applying."

Answered by AI

How many individuals are currently participating in this clinical trial?

"This trial necessitates the enrollment of 54 suitable patients. Subjects can be recruited from a variety of locations, such as Fred Hutchinson Cancer Research Center in Seattle and The Ohio State University located in Columbus."

Answered by AI

What is the intent of this experiment?

"Per the trial sponsor, Vincerx Pharma Inc., Maximum tolerated dose will be monitored over a three-year period to determine the primary outcome. Secondary outcomes such as Overall Survival Rate (Time Between First Dose Date and Date of Death), Progression Free Survival (Number of Participants Without Disease Progression per iwCLL guidelines for CLL & Lugano Classification for NHL) and Tumor Response (Tumor response evaluation based on the response criteria as applicable for CLL and Richter Syndrome) will also be evaluated."

Answered by AI

Are recruitment efforts underway in order to involve subjects for this research?

"Affirmative. According to clinicaltrials.gov, this trial is actively seeking volunteers; it was initially posted on December 16th 2021 and recently updated on August 3rd 2022. To meet the requirements of the study, 54 subjects need to be recruited from 4 medical locations."

Answered by AI
~2 spots leftby Apr 2025