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Chemotherapy

Radioimmunotherapy + Chemotherapy + Stem Cell Transplant for Lymphoma

Phase 1

Waitlist Available

Research Sponsored by Garden State Cancer Center at the Center for Molecular Medicine and Immunology

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Histologically or cytologically confirmed recurrent or refractory B-cell malignancy that has failed at least one standard therapy

Autologous peripheral blood stem cells (PBSC) or bone marrow available

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

Study Summary

This trial is studying how well giving a radiolabeled monoclonal antibody plus combination chemotherapy and peripheral stem cell transplantation works in treating patients with B-cell cancer.

Who is the study for?

This trial is for adults over 18 with B-cell cancer that's come back or hasn't responded to treatment. They should have tried at least one standard therapy, have a good heart and lung function, and no active brain tumors. Participants need available stem cells for transplant and can't be pregnant or imprisoned.Check my eligibility

What is being tested?

The study tests a combination of a radiolabeled monoclonal antibody with chemotherapy and stem cell transplantation in patients with recurrent or refractory B-cell malignancies to see if it's more effective in treating the cancer.See study design

What are the potential side effects?

Potential side effects may include reactions to the antibody, damage to normal cells from radiation, complications from high-dose chemotherapy like nausea, fatigue, infection risk increase due to weakened immune system after stem cell transplant.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My B-cell cancer has not responded to at least one standard treatment.

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I have my own stem cells or bone marrow available for use.

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My bilirubin level is below 2 mg/dL.

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I don't have severe loss of appetite, nausea, or vomiting.

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My kidney function, measured by creatinine, is within normal limits.

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I have a specific type of leukemia and my stem cells are mostly free of cancer.

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My condition is stage II to IV non-Hodgkin's lymphoma.

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I am 18 years old or older.

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My heart pumps blood effectively.

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My lung function tests are above 60% of what's expected.

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I do not have any active cancer spread to my brain.

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I have at least one tumor site targeted by a specific pretherapy.

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I can take care of myself and perform daily activities.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

0 / 13Eligibility criteria met

Find a Location

Who is running the clinical trial?

Garden State Cancer Center at the Center for Molecular Medicine and ImmunologyLead Sponsor

9 Previous Clinical Trials

123 Total Patients Enrolled

2 Trials studying Leukemia

39 Patients Enrolled for Leukemia

Jack D. Burton, MDStudy ChairGarden State Cancer Center at the Center for Molecular Medicine and Immunology

8 Previous Clinical Trials

114 Total Patients Enrolled

2 Trials studying Leukemia

39 Patients Enrolled for Leukemia

Media Library

Combination Chemotherapy (Chemotherapy) Clinical Trial Eligibility Overview. Trial Name: NCT00004086 — Phase 1

Leukemia Clinical Trial 2023: Combination Chemotherapy Highlights & Side Effects. Trial Name: NCT00004086 — Phase 1

Combination Chemotherapy (Chemotherapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00004086 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there still an opportunity for patients to join this research?

"As recorded on clinicaltrials.gov, the recruitment for this particular medical trial has been closed since June 6th 2009. Despite its closure, there are still 2,816 other trials that require patient participation at present time."

Answered by AI