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Monoclonal Antibodies

ABBV-181 for HIV

Phase 1
Waitlist Available
Research Sponsored by AbbVie
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to approximately 44 weeks
Awards & highlights

Study Summary

This trial will test the safety and effectiveness of ABBV-181 in HIV-1 infected people who are taking a break from their usual antiretroviral therapy.

Eligible Conditions
  • HIV
  • HIV/AIDS

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to approximately 44 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to approximately 44 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Area Under the Curve (AUCtau)
Half-life (t1/2)
Maximum Observed Concentration (Cmax)
+5 more

Trial Design

5Treatment groups
Experimental Treatment
Placebo Group
Group I: Stage 2: Arm EExperimental Treatment1 Intervention
Participants will receive ABBV-181 dose C.
Group II: Stage 1: Arm CExperimental Treatment1 Intervention
Participants will receive ABBV-181 dose B.
Group III: Stage 1: Arm BExperimental Treatment1 Intervention
Participants will receive ABBV-181 dose A.
Group IV: Stage 2: Arm DPlacebo Group1 Intervention
Participants will receive Placebo.
Group V: Stage 1: Arm APlacebo Group1 Intervention
Participants will receive placebo.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
ABBV-181
2013
Completed Phase 1
~500

Find a Location

Who is running the clinical trial?

AbbVieLead Sponsor
958 Previous Clinical Trials
502,343 Total Patients Enrolled
ABBVIE INC.Study DirectorAbbVie
397 Previous Clinical Trials
147,057 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any analogous studies regarding ABBV-181 that have been conducted previously?

"Presently, there are 6 running studies for the ABBV-181 drug with none of them in their concluding phase. The majority of these trials take place in Hamburg and Lazio, but research is being done at 178 medical centres worldwide."

Answered by AI

Has this particular medical trial been conducted previously?

"Presently, 6 trials related to ABBV-181 are taking place in 81 cities and 13 countries. In 2018, AbbVie sponsored the initial trial of this drug which had 233 participants and concluded its Phase 1 stage with success. Since then, 18330 research studies have been accomplished."

Answered by AI

Is this experiment presently recruiting participants?

"Unfortunately, no more patients can be registered for this clinical trial as recruitment is now closed. It originally appeared on 1/30/2020 and was last updated on 9/19/2022. For those searching for other studies, 695 trials are open to people with antibody deficiency syndrome and 6 medical experiments have vacancies for ABBV-181 participants."

Answered by AI

Are any individuals under the age of 25 being considered for participation in this examination?

"To qualify for this trial, patients must fall within the age range of 18 and 65. There are separate clinical trials available to individuals younger than 18 (195) or older than 65 (503)."

Answered by AI

Has ABBV-181 been given the go ahead by government regulators?

"Our assessment of ABBV-181's safety received a rating of 1 as this is an early stage trial, indicating limited evidence for both efficacy and patient protection."

Answered by AI

In what locations can people access this clinical experiment?

"At present, the trial is being conducted at 14 medical centres. These are situated in Miami Beach, Miami and Fort Pierce as well as other cities around the continental US. To reduce unnecessary travel costs, it's recommended that you choose a clinic close to your home should you decide to enrol."

Answered by AI

What is the current scale of recruitment to this medical experiment?

"As of the last update on September 19th 2022, this trial is not recruiting participants. However, if you are interested in participating in a study related to antibody deficiency syndrome there are presently 695 trials open and 6 studies actively accepting enrolment for ABBV-181."

Answered by AI

Do I fulfill the prerequisites to take part in this clinical experiment?

"This clinical experiment is recruiting 41 patients with an immunodeficiency disease aged 18 to 65. These participants must meet a set of criteria, including: BMI between 18.0 and 35 kg/m2., HIV-1 infection while receiving antiretroviral therapy (ART) for at least 12 months before screening., Plasma HIV-1 RNA below lower limit of quantification (LLOQ), CD4+ T cell count >= 500 cells/uL prior to screening and during the previous year, CD4+ T cell nadir of >= 200 cells/uL when exposed chronically., Willingness to temporarily suspend ART"

Answered by AI
~8 spots leftby Apr 2025