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Nitrates

Nitrates for Heart Failure

Phase 1
Waitlist Available
Led By Alison Morris, MD, MS
Research Sponsored by Gladwin, Mark, MD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 2 hours post drug administration and 6 hours post drug administration
Awards & highlights

Study Summary

This study is evaluating whether the oral microbiome may play a role in pulmonary hypertension.

Eligible Conditions
  • Heart Failure
  • Pulmonary Hypertension
  • Pulmonary Heart Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 2 hours post drug administration and 6 hours post drug administration
This trial's timeline: 3 weeks for screening, Varies for treatment, and at 2 hours post drug administration and 6 hours post drug administration for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Plasma Nitrate
Change in Urine Nitrate
Secondary outcome measures
Change in Pulmonary Vascular Resistance (PVR)

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Chlorhexidine Gluconate MouthwashExperimental Treatment2 Interventions
rinse with chlorhexidine gluconate 0.12% (15mL) mouthwash before administration of 14N Sodium Nitrate 1,000 mg/11.18 mmol, oral
Group II: Placebo MouthwashPlacebo Group2 Interventions
rinse with placebo mouthwash (15mL) before administration of 14N Sodium Nitrate 1,000 mg/11.18 mmol, oral

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

National Heart, Lung, and Blood Institute (NHLBI)NIH
3,837 Previous Clinical Trials
47,851,627 Total Patients Enrolled
207 Trials studying Heart Failure
677,448 Patients Enrolled for Heart Failure
University of PittsburghOTHER
1,722 Previous Clinical Trials
16,342,936 Total Patients Enrolled
13 Trials studying Heart Failure
2,869 Patients Enrolled for Heart Failure
Gladwin, Mark, MDLead Sponsor
14 Previous Clinical Trials
433 Total Patients Enrolled
4 Trials studying Heart Failure
146 Patients Enrolled for Heart Failure

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Chlorhexidine Mouthwash and Oral Nitrate in Adults With Pulmonary Hypertension
Alison Morris 2022. "Chlorhexidine Mouthwash and Oral Nitrate in Adults With Pulmonary Hypertension". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03787082.
~0 spots leftby Apr 2025
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