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Monoclonal Antibodies

SLN360 for Dyslipidemia

Phase 1
Waitlist Available
Research Sponsored by Silence Therapeutics plc
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 150 and day 201
Awards & highlights

Study Summary

This trial will study the effects of a new drug, SLN360, on patients with high levels of a substance called Lp(a).

Eligible Conditions
  • Dyslipidemia
  • High Cholesterol
  • Elevated Lipoprotein

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 150 and day 201
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 150 and day 201 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Incidence of treatment-emergent adverse events
Secondary outcome measures
Pharmacodynamic: Change in Lp(a)
Pharmacokinetic: apparent total clearance from plasma after s.c injection (CL/F)
Pharmacokinetic: area under the plasma concentration (AUC)
+1 more

Trial Design

11Treatment groups
Experimental Treatment
Placebo Group
Group I: 900 mgExperimental Treatment1 Intervention
Group II: 600 mg multi doseExperimental Treatment1 Intervention
Group III: 600 mgExperimental Treatment1 Intervention
Group IV: 300 mg multi doseExperimental Treatment1 Intervention
Group V: 300 mgExperimental Treatment1 Intervention
Group VI: 30 mgExperimental Treatment1 Intervention
Group VII: 200 mg multi doseExperimental Treatment1 Intervention
Group VIII: 100 mg multi doseExperimental Treatment1 Intervention
Group IX: 100 mgExperimental Treatment1 Intervention
Group X: Placebo multi dosePlacebo Group1 Intervention
Group XI: PlaceboPlacebo Group1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
SLN360
2020
Completed Phase 1
~70

Find a Location

Who is running the clinical trial?

Silence Therapeutics plcLead Sponsor
5 Previous Clinical Trials
313 Total Patients Enrolled
Medpace, Inc.Industry Sponsor
94 Previous Clinical Trials
29,545 Total Patients Enrolled
1 Trials studying Dyslipidemia
44 Patients Enrolled for Dyslipidemia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

How old are they?
65+
What site did they apply to?
Jacksonville Center for Clinical Research Ltd.
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
JamaJournal
Single Ascending Dose Study of a Short Interfering RNA Targeting Lipoprotein(a) Production in Individuals with Elevated Plasma Lipoprotein(a) Levels
Nissen, Steven E., Kathy Wolski, Craig Balog, Daniel I. Swerdlow, Alison C. Scrimgeour, Curtis Rambaran, Rosamund J. Wilson, et al.. 2022. “Single Ascending Dose Study of a Short Interfering RNA Targeting Lipoprotein(a) Production in Individuals with Elevated Plasma Lipoprotein(a) Levels”. Jama. American Medical Association (AMA). doi:10.1001/jama.2022.5050.
JamaJournal
Single Ascending Dose Study of a Short Interfering RNA Targeting Lipoprotein(a) Production in Individuals with Elevated Plasma Lipoprotein(a) Levels
Nissen, Steven E., Kathy Wolski, Craig Balog, Daniel I. Swerdlow, Alison C. Scrimgeour, Curtis Rambaran, Rosamund J. Wilson, et al.. 2022. “Single Ascending Dose Study of a Short Interfering RNA Targeting Lipoprotein(a) Production in Individuals with Elevated Plasma Lipoprotein(a) Levels”. Jama. American Medical Association (AMA). doi:10.1001/jama.2022.5050.
clinicaltrials.govStudy
Study to Investigate Safety, Tolerability, PK and PD Response of SLN360 in Subjects With Elevated Lipoprotein(a)
2020. "Study to Investigate Safety, Tolerability, PK and PD Response of SLN360 in Subjects With Elevated Lipoprotein(a)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04606602.
~16 spots leftby Apr 2025
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