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mTOR inhibitor

Rapamune for Heart Failure

Phase 1
Waitlist Available
Led By Mandeep Singh, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

This trial will test whether the drug rapamycin can help improve heart function by increasing oxygen consumption.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change cardiopulmonary reserve capacity by improving peak VO2 with rapamycin

Side effects data

From 2014 Phase 1 & 2 trial • 30 Patients • NCT00286156
60%
Nonserious infections
60%
Oral ulcerations
40%
Miscellaneous/other
30%
Gastrointestinal symptoms
10%
Decrease visual acuity
10%
Edema
10%
nephrotic range proteinuria
100%
80%
60%
40%
20%
0%
Study treatment Arm
Standard Rapamycin Dose (STD)
Low Dose Rapamycin (LD)
Standard Care

Trial Design

1Treatment groups
Experimental Treatment
Group I: RapamycinExperimental Treatment1 Intervention
find safe doses for patients who have heart failure with preserved ejection fraction
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Rapamune
2020
Completed Phase 2
~80

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,209 Previous Clinical Trials
3,767,110 Total Patients Enrolled
72 Trials studying Heart Failure
1,022,004 Patients Enrolled for Heart Failure
Mandeep Singh, MDPrincipal Investigator - Mayo Clinic
Mayo Clinic Rochester, Mayo HIV Clinic - Rochester
J N Medical College (Medical School)
Mayo Grad School Med/Mayo Fndn (Residency)
5 Previous Clinical Trials
314 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
Colorado
How old are they?
18 - 65
What site did they apply to?
Mayo Clinic Rochester
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Effect of Rapamycin to Improve Cardiac Function in Frail Older Adults
Mandeep Singh 2022. "Effect of Rapamycin to Improve Cardiac Function in Frail Older Adults". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04996719.
~8 spots leftby Apr 2025
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