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BMS-986447 Safety and Tolerability for Healthy Subjects

Phase 1
Waitlist Available
Research Sponsored by Bristol-Myers Squibb
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 72 hours postdose
Awards & highlights

Study Summary

This trial tests the safety and effectiveness of a new drug in healthy people to see if it can be used safely.

Who is the study for?
This trial is for healthy men and women with a body mass index (BMI) between 18 and 30. Participants must have no significant medical issues based on their history, physical exams, ECGs, or lab tests. They also need to test negative for COVID-19 before starting the study.Check my eligibility
What is being tested?
The study is testing BMS-986447, which participants will take as a single oral dose. The goal is to see how safe it is, how well people can tolerate it, and how the drug levels change in the body over time. Some participants will receive a placebo instead of the actual drug.See study design
What are the potential side effects?
Since this trial aims to determine safety and tolerability, specific side effects are not listed beforehand but will be monitored throughout the study.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 72 hours postdose
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 72 hours postdose for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Participants with Adverse Events (AEs)
Number of Participants with Clinical Laboratory Abnormalities
Number of Participants with Electrocardiogram (ECG) Abnormalities
+3 more
Secondary outcome measures
Apparent terminal phase half-life (T-Half)
Maximum observed plasma concentration (Cmax)
Time of maximum observed plasma concentration (Tmax)

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: BMS-986447Experimental Treatment1 Intervention
Group II: PlaceboPlacebo Group1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
BMS-986447
2023
Completed Phase 1
~40

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Bristol-Myers SquibbLead Sponsor
2,639 Previous Clinical Trials
4,128,968 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research allowance for the participation of young adults?

"In accordance with the requirements of this clinical trial, prospective participants must fall between 18 and 55 years old."

Answered by AI

Has the FDA passed judgment on BMS-986447 yet?

"With a score of 1, our team at Power consider BMS-986447 to be moderately safe due its Phase 1 status. This signifies that there is restricted data available in regards to the medication's efficacy and safety."

Answered by AI

How many participants are allowed to join this research program?

"Affirmative. According to information posted on clinicaltrials.gov, this study is actively seeking participants since it was first shared on March 10th 2023 and last updated on June 30th of the same year. It desires 32 patients from a single medical centre."

Answered by AI

Are there still available openings for participants of this research?

"This research trial, first published on March 10th 2023, is actively looking for participants. The most recent update was posted on June 30th of the same year."

Answered by AI

Would I be considered an appropriate candidate for this experiment?

"To meet the criteria of this clinical trial, healthy individuals aged 18-55 are sought after. The investigators plan to recruit 32 patients in total."

Answered by AI

Who else is applying?

What state do they live in?
California
What site did they apply to?
Anaheim Clinical Trials, LLC
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

I am interested in helping researchers better understand their proposed interventions and their safe use on patients.
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
A Study to Evaluate the Safety, Tolerability and Drug Levels of BMS-986447 in Healthy Participants
2023. "A Study to Evaluate the Safety, Tolerability and Drug Levels of BMS-986447 in Healthy Participants". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05760937.
~15 spots leftby Apr 2025
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