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Cohort 3 for Glioblastoma

Phase 1
Waitlist Available
Led By Andrew Sloan, MD
Research Sponsored by Stanton Gerson MD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Study Summary

This trial will study O6-benzylguanine and temozolomide in combination with genetically modified peripheral blood stem cells to treat patients with newly diagnosed glioblastoma multiforme.

Eligible Conditions
  • Glioblastoma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Feasibility and safety of infusing autologous P140K MGMT-transduced hematopoietic progenitors into patients with GBM
Secondary outcome measures
Number of patients with radiological progression
Overall Survival
Progression-free
+2 more

Trial Design

3Treatment groups
Active Control
Group I: Cohort 3Active Control7 Interventions
Intra patient dose escalation of TMZ in patients with evidence of P140K marked cells
Group II: Cohort 1Active Control7 Interventions
LV gene transfer after concurrent chemo-radiotherapy
Group III: Cohort 2Active Control7 Interventions
LV gene transfer prior to concurrent chemo-radiotherapy

Find a Location

Who is running the clinical trial?

Stanton Gerson MDLead Sponsor
National Cancer Institute (NCI)NIH
13,646 Previous Clinical Trials
40,931,017 Total Patients Enrolled
322 Trials studying Glioblastoma
23,105 Patients Enrolled for Glioblastoma
Andrew Sloan, MDPrincipal InvestigatorUniversity Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center
4 Previous Clinical Trials
133 Total Patients Enrolled
3 Trials studying Glioblastoma
60 Patients Enrolled for Glioblastoma

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
BG & TMZ Therapy of Glioblastoma Multiforme
Stanton Gerson MD 2011. "BG & TMZ Therapy of Glioblastoma Multiforme". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01269424.
~1 spots leftby Apr 2025
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