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Flavonoid

Quercetin for Fanconi Anemia

Phase 1

Waitlist Available

Led By Parinda Mehta, MD

Research Sponsored by Children's Hospital Medical Center, Cincinnati

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 4 month (16 weeks) and 1 year

Awards & highlights

Study Summary

This trial is testing a new way to treat people with Fanconi anemia, which is a disease that causes bone marrow failure and other problems.

Eligible Conditions

Fanconi Anemia

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 4 month (16 weeks) and 1 year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~4 month (16 weeks) and 1 year

This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 month (16 weeks) and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Measure safety of oral quercetin therapy in patients with FA

Measure the ability to administer twice daily oral quercetin therapy in patients with Fanconi Anemia (FA).

Therapeutic procedure

Secondary outcome measures

Measure the preservation of hematopoietic stem cell reserve in patients with FA

Number of participants with improved hematopoiesis.

To measure the impact of quercetin therapy on changes in insulin sensitivity/glucose tolerance.

+1 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Quercetin - Dietary SupplementExperimental Treatment1 Intervention

Quercetin will be given orally on a twice a day schedule starting with weight adjusted dose for a maximum total daily dose of 1500 mg/day, for 4 months (16 weeks). Pharmacokinetics (PK) data will be analyzed after each cohort of 3 patients and will be used to optimize the dosing schedule (if required) for subsequent patients. An expansion cohort has been added to the study protocol. Up to 20 patients may be enrolled. The dose utilized will be the same as the max weight adjusted dose that showed biological activity in our last cohort of patients (subjects #10-12 from above).

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Quercetin (dietary supplement)

2012

Completed Phase 1

~30

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Find a Location

Who is running the clinical trial?

Children's Hospital Medical Center, CincinnatiLead Sponsor

815 Previous Clinical Trials

6,531,566 Total Patients Enrolled

9 Trials studying Fanconi Anemia

230 Patients Enrolled for Fanconi Anemia

Food and Drug Administration (FDA)FED

171 Previous Clinical Trials

1,331,576 Total Patients Enrolled

Parinda Mehta, MDPrincipal InvestigatorChildren's Hospital Medical Center, Cincinnati

5 Previous Clinical Trials

188 Total Patients Enrolled

1 Trials studying Fanconi Anemia

70 Patients Enrolled for Fanconi Anemia

Media Library

Quercetin (Flavonoid) Clinical Trial Eligibility Overview. Trial Name: NCT01720147 — Phase 1

Fanconi Anemia Research Study Groups: Quercetin - Dietary Supplement

Fanconi Anemia Clinical Trial 2023: Quercetin Highlights & Side Effects. Trial Name: NCT01720147 — Phase 1

Quercetin (Flavonoid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01720147 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Quercetin (dietary supplement) a hazard to individuals' health?

"Our experts gave Quercetin (dietary supplement) a rating of 1 because this is an early-stage study with limited supporting data on its efficacy and safety."

Answered by AI

What other experiments have been performed with regards to Quercetin as a dietary supplement?

"Currently, 10 clinical trials are in progress for Quercetin (dietary supplement). None of these ongoing investigations is at the Phase 3 stage. Montreal, Quebec serves as the primary location for this research; however there are additional sites in other cities participating."

Answered by AI

Are additional participants currently being sought for this investigation?

"This particular trial is not longer enrolling participants. The initial posting occured on July 1st 2012 and the most recent update was recorded in January 3rd 2022. On the other hand, if you are looking for alternatives, there are currently 225 trials recruiting patients with Fanconi anemia and 10 studies seeking subjects to take Quercetin (dietary supplement)."

Answered by AI

What is the maximum number of participants allowed in this experiment?

"This medical trial is no longer searching for participants. The study was first posted on July 1st 2012 and the most recent update came in March of 2022. However, there are currently 225 other trials actively recruiting patients with Fanconi Anemia and 10 research projects looking to include individuals who take Quercetin (a dietary supplement)."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Quercetin in Children With Fanconi Anemia; a Pilot Study

2012. "Quercetin in Children With Fanconi Anemia; a Pilot Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01720147.