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Chemotherapy

Amifostine for Fanconi Anemia

Phase 1

Waitlist Available

Research Sponsored by Dana-Farber Cancer Institute

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Refusal of or unsuccessful with prior conventional therapies

Diagnosis of Fanconi's anemia by conventional diepoxybutane or mitomycin sensitivity assays, or molecular testing

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

Study Summary

This trial is testing a drug called amifostine in patients with bone marrow failure related to Fanconi's anemia. The goal is to see if it is safe and effective, and if it affects bone marrow progenitor cell proliferation and peripheral blood mononuclear cell apoptosis.

Who is the study for?

This trial is for patients with Fanconi's anemia who have experienced bone marrow failure. Participants must have a confirmed diagnosis through specific tests and should not be pregnant or have active infections, kidney/liver problems, prior cancer, or previous bone marrow transplant.Check my eligibility

What is being tested?

The study is testing the safety and effectiveness of amifostine in treating bone marrow failure related to Fanconi's anemia. It will also look at how this drug affects bone marrow cell growth and blood cell survival.See study design

What are the potential side effects?

While the trial description does not list specific side effects, amifostine commonly causes nausea, vomiting, low blood pressure, dizziness, and allergic reactions. The severity can vary from person to person.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have tried or refused standard treatments without success.

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I have been diagnosed with Fanconi's anemia through specific tests.

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My blood tests show low counts indicating bone marrow failure.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Dana-Farber Cancer InstituteLead Sponsor

1,079 Previous Clinical Trials

340,927 Total Patients Enrolled

W. Nicholas HainingStudy ChairDana-Farber Cancer Institute

Media Library

Amifostine (Chemotherapy) Clinical Trial Eligibility Overview. Trial Name: NCT00006127 — Phase 1

Diamond-Blackfan Anemia Research Study Groups:

Diamond-Blackfan Anemia Clinical Trial 2023: Amifostine Highlights & Side Effects. Trial Name: NCT00006127 — Phase 1

Amifostine (Chemotherapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00006127 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What criteria must participants meet to be included in this medical experiment?

"In this study, 21 individuals with congenital hypoplastic anemia aged 2 and older must meet certain prerequisites. These include refusing or failing previous conventional treatments as well not being under concurrent androgen therapy. Additionally, there are disease-specific requirements that need to be fulfilled."

Answered by AI

Is this form of therapy approved by the relevant regulatory bodies?

"Due to it being a Phase 1 trial, which implies that there is only limited data supporting both efficacy and safety of the medication, our team at Power has rated this treatment's security with a score of 1."

Answered by AI

Is this investigation accepting seniors as participants?

"The eligibility criteria for this clinical trial requires participants to be between 2 and 0 years of age."

Answered by AI

Is there still room to join this experiment as a participant?

"Data on clinicaltrials.gov reveals that this particular medical trial, which was initially posted 4/1/2000 and last edited 6/23/2005, is not presently looking for participants. However, there are 226 other trials actively seeking out patients at the moment."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Phase I Study of Amifostine in Patients With Bone Marrow Failure Related to Fanconi's Anemia

2000. "Phase I Study of Amifostine in Patients With Bone Marrow Failure Related to Fanconi's Anemia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00006127.

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