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Aerobic Exercise for Epilepsy

Phase 1

Recruiting

Led By Jonathan J Russin, MD

Research Sponsored by University of Southern California

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Candidacy for standard or selective temporal lobectomy

Age of 18 years or older

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through study completion, an average of 6 months

Awards & highlights

Study Summary

This trial will test whether a six-month aerobic exercise regimen can improve cognition in 100 epilepsy patients.

Who is the study for?

This trial is for adults aged 18-65 with medically resistant mesial temporal lobe epilepsy who may undergo a lobectomy. It's not for those over 65, pregnant women, individuals unable to exercise due to physical or medical reasons, or those with cognitive disabilities that prevent participation in an exercise program.Check my eligibility

What is being tested?

The study tests the effects of high and low-impact aerobic exercises on brain regeneration and cognitive improvement in epilepsy patients. The goal is to see if exercising can stimulate neurogenesis (growth of new neurons) which might help improve memory and cognition.See study design

What are the potential side effects?

While specific side effects are not listed, typical risks associated with aerobic exercise may include muscle soreness, fatigue, joint stress, or injury. Participants should be monitored for any adverse reactions related to their condition.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am a candidate for surgery on the temporal lobe of my brain.

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I am 18 years old or older.

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I have been diagnosed with hard-to-treat epilepsy in the inner part of my temporal lobe.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through study completion, an average of 6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through study completion, an average of 6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Adherence to exercise and assessments

Secondary outcome measures

Neurogenesis

Rey Auditory Verbal Learning Test (RAVLT) - Summary score

Rey Auditory Verbal Learning Test (RAVLT) - Trial V

+2 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: High-impact ExerciseExperimental Treatment1 Intervention

Group II: Low-impact ExerciseActive Control1 Intervention

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Southern CaliforniaLead Sponsor

906 Previous Clinical Trials

1,596,278 Total Patients Enrolled

Jonathan J Russin, MDPrincipal InvestigatorUniversity of Southern California

Media Library

High-Impact Aerobic Exercise Clinical Trial Eligibility Overview. Trial Name: NCT05179083 — Phase 1

Temporal Lobe Epilepsy Research Study Groups: High-impact Exercise, Low-impact Exercise

Temporal Lobe Epilepsy Clinical Trial 2023: High-Impact Aerobic Exercise Highlights & Side Effects. Trial Name: NCT05179083 — Phase 1

High-Impact Aerobic Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT05179083 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there vacancies in this clinical research program?

"Confirmed. Clinicaltrials.gov reports that this trial, initially made available on August 20th 2022 is actively recruiting individuals for participation. This information was most recently updated on the same date as well."

Answered by AI

How can intense aerobic exercise impact a patient's health?

"As this is a Phase 1 clinical trial, which has limited evidence of safety and efficacy, our team at Power gauged the potential danger posed by High-Impact Aerobic Exercise to be low, giving it an overall rating of 1 on our scale."

Answered by AI

Is the study recruiting elderly participants?

"The requirements for this trial necessitate that participants are between the ages of 18 to 65. Separately, there are 103 trials available specifically for minors and 157 trials created exclusively for those over 65 years old."

Answered by AI

How many people have enrolled in this clinical experiment?

"Affirmative. Clinicaltrials.gov lists this clinical trial as actively recruiting patients, with the initial posting being on August 20th 2022 and last updated also occuring on that date. The study seeks out 10 individuals from a single medical centre."

Answered by AI

Who is eligible to be a study participant for this experiment?

"This clinical study is seeking 10 adults between 18-65 years old who suffer from temporal lobe epilepsy (TLE) and are qualified for either standard or selective temporal lobectomy."

Answered by AI

Recent research and studies

Annals of NeurologyJournal

The Burden of Neurological Disease in the United States: A Summary Report and Call to Action

Gooch, Clifton L., Etienne Pracht, and Amy R. Borenstein. 2017. “The Burden of Neurological Disease in the United States: A Summary Report and Call to Action”. Annals of Neurology. Wiley. doi:10.1002/ana.24897.

clinicaltrials.govStudy

Exercise for Brain Regeneration in Epilepsy

Jonathan Russin 2022. "Exercise for Brain Regeneration in Epilepsy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05179083.

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