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OrganOx Metra for Liver Disease

Phase 1
Waitlist Available
Led By David R Grant, MD
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months
Awards & highlights

Study Summary

This trial will study whether it is safe to transport and store livers in a machine that keeps them at body temperature. Participants will be followed for 3 months after transplant surgery.

Eligible Conditions
  • End Stage Liver Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Rates of primary graft non-function
Rates of re-transplantation
Rates of recipient death
Secondary outcome measures
Ischemia- reperfusion injury associated with organ storage
Rate of device failures resulting in organ discard
Recruitment rates to the study
+2 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: OrganOx MetraExperimental Treatment1 Intervention
OrganOx Metra Device

Find a Location

Who is running the clinical trial?

University Health Network, TorontoLead Sponsor
1,476 Previous Clinical Trials
485,140 Total Patients Enrolled
David R Grant, MDPrincipal InvestigatorUniversity Health Network, Toronto

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who fits the parameters to be a candidate for this clinical trial?

"End-stage liver disease (esld) is a requirement for admittance into this clinical trial. Additionally, all participants must be between 18 and 70 years old. Only 40 individuals will be accepted into the study."

Answered by AI

Is this study's age limit 45 years or older?

"The target population for this clinical trial are individuals who have not yet reached their seventies and are of legal age."

Answered by AI

Are researchers still looking for volunteers for this trial?

"No, the clinical trial is not recruiting at this time. It was first posted on July 1st, 2015 and was last updated on April 8th, 2022. However, there are other medical studies that are actively looking for participants."

Answered by AI

While taking OrganOx Metra, what are patients' risks?

"Given that this is a Phase 1 trial with limited safety data, our team has conservatively given OrganOx Metra a score of 1."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Using Ex-vivo Normothermic Machine Perfusion With the Organox Metra™ Device to Store Human Livers for Transplantation
2015. "Using Ex-vivo Normothermic Machine Perfusion With the Organox Metra™ Device to Store Human Livers for Transplantation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02478151.
~4 spots leftby Apr 2025
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