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Treatment sequence B-A for High Cholesterol

Phase 1

Waitlist Available

Research Sponsored by AstraZeneca

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up pre-dose, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 12, 24, 36 and 48 hours post-dose

Awards & highlights

Study Summary

This trial studies how a new drug (AZD0780) interacts with an existing drug (rosuvastatin) and how safe it is when taken alone or together.

Eligible Conditions

High Cholesterol

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ pre-dose, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 12, 24, 36 and 48 hours post-dose

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~pre-dose, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 12, 24, 36 and 48 hours post-dose

This trial's timeline: 3 weeks for screening, Varies for treatment, and pre-dose, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 12, 24, 36 and 48 hours post-dose for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Apparent total body clearance (CL/F) of AZD0780

Apparent total body clearance (CL/F) of Rosuvastatin

Apparent volume of distribution during the terminal phase after extravascular administration (Vz/F) of AZD0780

+11 more

Secondary outcome measures

Number of participants with Adverse Events

Trial Design

2Treatment groups

Experimental Treatment

Group I: Treatment sequence B-AExperimental Treatment2 Interventions

Participants will receive 1 treatment during each study period in the following sequence: a single dose of rosuvastatin tablet + AZD0780 tablet (Treatment B) in period 1 and then a single dose of rosuvastatin tablet alone (Treatment A) in period 2.

Group II: Treatment sequence A-BExperimental Treatment2 Interventions

Participants will receive treatments in the following sequence, a single dose of rosuvastatin tablet alone (Treatment A) in period 1, and then a single dose of rosuvastatin tablet + Dose X AZD0780 tablet (Treatment B) in period 2.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

AZD0780

2023

Completed Phase 1

~20

Rosuvastatin

2019

Completed Phase 4

~3150

Do I qualify?Apply below to find out

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

AstraZenecaLead Sponsor

4,257 Previous Clinical Trials

288,593,770 Total Patients Enrolled

9 Trials studying High Cholesterol

11,022 Patients Enrolled for High Cholesterol

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this examination open to participants older than 30 years of age?

"As specified in the enrollment conditions, prospective participants must be aged 18 or above and below 60 years old."

Answered by AI

What qualifications must I meet to join this research trial?

"In order to be accepted into this clinical trial, candidates must have elevated cholesterol levels and fall between the ages of 18-60. A total of 16 people can join this study."

Answered by AI

Is sequence A-B a secure option for patients?

"With limited data to reference and evaluate safety, Treatment sequence A-B received a score of 1 on our team's assessment scale. This is reflective of the Phase 1 nature of this clinical trial."

Answered by AI

How many participants have thus far been signed up for this research project?

"Affirmative. Clinicaltrials.gov denotes that this clinical trial is currently in the recruitment phase, with a posting date of March 9th 2023 and an edit date of March 27th 2023. A total of 16 participants are needed from 1 research site for successful completion of the study."

Answered by AI

Are participants currently being enrolled for this trial?

"Confirmed. The clinical trial is actively recruiting, with the first post having been made on March 9th 2023 and recently updated on March 27th of the same year. 16 individuals are sought to participate in this study at a single site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

A Study to Assess the Effect of AZD0780 on the Pharmacokinetics of Rosuvastatin.

2023. "A Study to Assess the Effect of AZD0780 on the Pharmacokinetics of Rosuvastatin.". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05787002.