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Harmine Hydrochloride Capsules for Diabetes

Phase 1
Waitlist Available
Led By James Murrough, MD, PhD
Research Sponsored by James Murrough
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up end of study, at 18 months
Awards & highlights

Summary

This trial is testing how much of the drug harmine healthy volunteers can tolerate. The goal is to find the maximum dose that is safe.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~end of study, at 18 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and end of study, at 18 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Dose Limiting Toxicity (DLT)
Secondary outcome measures
Visual Analog Scale (VAS)

Trial Design

1Treatment groups
Experimental Treatment
Group I: Harmine DoseExperimental Treatment1 Intervention
There will be a total of seven possible doses that include 100 mg, 200 mg, 300 mg, 500 mg, 700 mg, 900 mg and 1200 mg. Each study subject will receive a single oral dose of harmine in this single ascending dose design.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Harmine Hydrochloride Capsules
2022
Completed Phase 1
~30

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

James MurroughLead Sponsor
8 Previous Clinical Trials
234 Total Patients Enrolled
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,381 Previous Clinical Trials
4,315,075 Total Patients Enrolled
107 Trials studying Diabetes
138,788 Patients Enrolled for Diabetes
James Murrough, MD, PhDPrincipal InvestigatorIcahn School of Medicine at Mount Sinai
5 Previous Clinical Trials
347 Total Patients Enrolled
~10 spots leftby Jul 2025
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