Study of Harmine in Healthy Subjects
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing harmine to find out how much can be safely given to people. Healthy volunteers will receive one amount of harmine, and researchers will check for any side effects. The information will help decide the next amount for the next person.
Will I have to stop taking my current medications?
Yes, you will need to stop taking certain medications. The trial does not allow medications that affect the central nervous system or cardiovascular system, as well as some over-the-counter drugs and herbal remedies. It's best to discuss your current medications with the trial team to see if they are allowed.
Is Harmine Hydrochloride generally safe for humans?
The available research does not provide specific safety data for Harmine Hydrochloride Capsules. However, general drug safety data suggests that while many drugs are safe, some can have serious side effects, and safety advisories are issued for emerging harms. It's important to consult healthcare professionals for personalized advice.12345
How does the drug Harmine Hydrochloride Capsules differ from other treatments for cancer?
Harmine Hydrochloride Capsules are unique because they have shown the ability to inhibit cancer cell growth in a time-dose-dependent manner, and they can be administered locally to reduce side effects, unlike systemic treatments that may cause central nervous toxicity. This local administration allows for prolonged drug presence at the tumor site, potentially enhancing its effectiveness.678910
Who Is on the Research Team?
James Murrough, MD, PhD
Principal Investigator
Icahn School of Medicine at Mount Sinai
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single oral dose of harmine in a dose escalation design
Monitoring
Participants are monitored for adverse events and dose limiting toxicities for 24 hours post-dosing
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Harmine Hydrochloride Capsules
Find a Clinic Near You
Who Is Running the Clinical Trial?
James Murrough
Lead Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator