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Alpha-2 Adrenergic Agonist

Clonidine for Cutaneous Nerve Itch

Phase 1
Waitlist Available
Research Sponsored by University of Minnesota
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 month
Awards & highlights

Study Summary

This trial will assess the safety and effectiveness of two drugs, clonidine and naltrexone, for treating symptoms of atopic dermatitis.

Eligible Conditions
  • Cutaneous Nerve Itch

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 month
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 month for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Reduction in Itch

Trial Design

2Treatment groups
Experimental Treatment
Group I: NaltrexoneExperimental Treatment1 Intervention
Naltrexone will be given to each subject at an oral dose of 50 mg daily. Subjects will self-administer the drug at bedtime.
Group II: ClonidineExperimental Treatment1 Intervention
Clonidine will be given orally as a starting dose of 0.1 mg daily. The drug will be administered orally by the subject at bedtime daily for four weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Clonidine
2010
Completed Phase 4
~1890
Naltrexone
2005
Completed Phase 4
~2420

Find a Location

Who is running the clinical trial?

University of MinnesotaLead Sponsor
1,380 Previous Clinical Trials
1,588,737 Total Patients Enrolled
Maria Hordinsky, MDStudy ChairUniversity of Minnesota
16 Previous Clinical Trials
450 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Treatment of Chronic Itch in Atopic Dermatitis (Eczema): Nerve Function
2015. "Treatment of Chronic Itch in Atopic Dermatitis (Eczema): Nerve Function". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02268448.
~1 spots leftby Apr 2025
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