[11C]UCB-J radiotracer for Melancholia

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Melancholia+2 More
[11C]UCB-J radiotracer - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial will use a radioactive marker to study if transcranial magnetic stimulation can help with changes in the brain linked to depression.

Eligible Conditions
  • Melancholia
  • Major Depressive Disorder (MDD)

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Melancholia

Study Objectives

1 Primary · 0 Secondary · Reporting Duration: Assessed during PET scans before and after rTMS therapy (90 minutes per scan)

Assessed during PET scans before and after rTMS therapy (90 minutes per scan)
Change in Synaptic Density Quantified by Regional Binding Potential (BP_ND)

Trial Safety

Safety Progress

1 of 3

Other trials for Melancholia

Trial Design

1 Treatment Group

Major Depression Disorder Participants
1 of 1
Experimental Treatment

10 Total Participants · 1 Treatment Group

Primary Treatment: [11C]UCB-J radiotracer · No Placebo Group · Phase 1

Major Depression Disorder ParticipantsExperimental Group · 2 Interventions: [11C]UCB-J radiotracer, PET-MR · Intervention Types: Drug, Device

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: assessed during pet scans before and after rtms therapy (90 minutes per scan)

Who is running the clinical trial?

Stanford UniversityOTHER
2,148 Previous Clinical Trials
35,678,994 Total Patients Enrolled
Davidzon, Guido, M.D.Lead Sponsor
1 Previous Clinical Trials
60 Total Patients Enrolled
Jong H Yoon, MDPrincipal InvestigatorStanford University
1 Previous Clinical Trials
60 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 9 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You are on a stable medication regimen for at least two weeks prior to testing.
You have the ability to undergo cognitive testing, clinical assessments, and PET/MR scans.
You are able to complete a PET-MRI scan without the use of sedation.
You will undergo rTMS treatment at the VA Palo Alto.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 2nd, 2021

Last Reviewed: October 17th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

References