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rTMS for Depression

Phase 1
Waitlist Available
Led By Jong H Yoon, MD
Research Sponsored by Davidzon, Guido, M.D.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up assessed during pet scans before and after rtms therapy (90 minutes per scan)
Awards & highlights

Study Summary

This trial will use a radioactive marker to study if transcranial magnetic stimulation can help with changes in the brain linked to depression.

Eligible Conditions
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~assessed during pet scans before and after rtms therapy (90 minutes per scan)
This trial's timeline: 3 weeks for screening, Varies for treatment, and assessed during pet scans before and after rtms therapy (90 minutes per scan) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Synaptic Density Quantified by Regional Binding Potential (BP_ND)

Trial Design

1Treatment groups
Experimental Treatment
Group I: Major Depression Disorder ParticipantsExperimental Treatment2 Interventions
Participants will undergo positron emission tomography-magnetic resonance (PET-MR) imaging using the [11C]UCB-J radiotracer before and after Repetitive Transcranial Magnetic Stimulation (rTMS) treatment

Find a Location

Who is running the clinical trial?

Davidzon, Guido, M.D.Lead Sponsor
2 Previous Clinical Trials
61 Total Patients Enrolled
Stanford UniversityOTHER
2,386 Previous Clinical Trials
17,333,998 Total Patients Enrolled
106 Trials studying Depression
93,734 Patients Enrolled for Depression
Jong H Yoon, MDPrincipal InvestigatorStanford University
1 Previous Clinical Trials
60 Total Patients Enrolled

Media Library

[11C]UCB-J radiotracer Clinical Trial Eligibility Overview. Trial Name: NCT04311619 — Phase 1
Depression Research Study Groups: Major Depression Disorder Participants
Depression Clinical Trial 2023: [11C]UCB-J radiotracer Highlights & Side Effects. Trial Name: NCT04311619 — Phase 1
[11C]UCB-J radiotracer 2023 Treatment Timeline for Medical Study. Trial Name: NCT04311619 — Phase 1
Depression Patient Testimony for trial: Trial Name: NCT04311619 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this experiment a fresh undertaking?

"At the present moment, 7 trials concerning [11C]UCB-J radiotracer are being held in 11 cities and 3 countries. This medication was originally tested back in 2018 by RDD Pharma Ltd., who recruited 40 patient for a Phase 1 trial. Since then, an additional 53 studies have been conducted on this tracer drug."

Answered by AI

How many individuals are involved in the research endeavor?

"This clinical trial is no longer accepting applicants. It was originally published on February 1, 2022 and the most recent edits were made on September 20, 2021. For those searching for another medical study to partake in, there are 826 trials currently enrolling melancholic patients and 7 studies recruiting participants for [11C]UCB-J radiotracer testing."

Answered by AI

What prior experiments have utilized the [11C]UCB-J radiotracer?

"Presently, 7 clinical trials of [11C]UCB-J radiotracer are ongoing. None have reached Phase 3 yet. Most experiments occur in Raleigh, North carolina; however, the therapy is being tested at 12 different sites around the US."

Answered by AI

Are adults aged 20 and above eligible to participate in this experiment?

"The study is accepting patients between 18 and 70, with 106 trials for minors and 600 for those older than 65."

Answered by AI

What medical indications have been successfully addressed with [11C]UCB-J?

"The [11C]UCB-J radiotracer is effective in treating anesthesia, conduction, persistent facial erythema, and rhinorrhoea."

Answered by AI

Has the [11C]UCB-J radiotracer achieved FDA clearance?

"The safety of [11C]UCB-J radiotracer is given a score of 1 by our team at Power, as this falls under Phase 1 trials and thus has limited data confirming its efficacy and security."

Answered by AI

Am I able to join this research program?

"This trial is accepting 10 individuals aged 18-70 suffering from melancholia. Moreover, successful applicants must be on a stable medication plan for two weeks prior to the start of testing, have secure living arrangements and medical health, and agree to receive repetitive Transcranial magnetic stimulation (rTMS) at VA Palo Alto Health Care System."

Answered by AI

Are recruitment efforts currently underway for this experimental research?

"This trial, which was first advertised on February 1st 2022, is no longer actively recruiting. As seen in the clinicaltrials.gov database, this medical research project's last update was on September 20th 2021; yet 833 other trials are currently looking for participants."

Answered by AI

Who else is applying?

What state do they live in?
California
What site did they apply to?
VA Palo Alto Health Care System
Stanford University
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
3+

Why did patients apply to this trial?

I've tried many other medications for major depressive disorder. A couple of them worked for a short time; the others didn't work at all. I'm still trying to find a cure.
PatientReceived 2+ prior treatments
Recent research and studies
~1 spots leftby Feb 2025