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Cancer Vaccine

Treatment (CMV-alphaDC1) for Blood Cancers

Phase 1
Waitlist Available
Led By George L Chen
Research Sponsored by Roswell Park Cancer Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 2 years
Awards & highlights

Summary

This trial tests a special vaccine to help patients who have had a specific medical procedure fight off a virus. The vaccine uses special cells to teach the immune system to recognize and attack the virus.

Eligible Conditions
  • Blood Cancer
  • Cytomegalovirus

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 2 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Incidence of dose limiting toxicities
T-Lymphocyte
T-Lymphocyte
Secondary study objectives
Incidence of late CMV reactivation after allogeneic hematopoietic stem cell transplant
Perinatal death
Other study objectives
Incidence of adverse events
T-Lymphocyte
T-Cell Receptor

Trial Design

1Treatment groups
Experimental Treatment
Group I: Treatment (CMV-alphaDC1)Experimental Treatment3 Interventions
Patients undergo standard of care allogeneic hematopoietic stem cell transplant on day 0 and receive CMV-alphaDC1 vaccine intradermally on days 28, 42, 56, and 70.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Biospecimen Collection
2004
Completed Phase 3
~2020
Allogeneic Hematopoietic Stem Cell Transplantation
2012
Completed Phase 2
~1240

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Roswell Park Cancer InstituteLead Sponsor
408 Previous Clinical Trials
32,405 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,868 Previous Clinical Trials
41,010,837 Total Patients Enrolled
2 Trials studying Blood Cancers
112 Patients Enrolled for Blood Cancers
George L ChenPrincipal InvestigatorRoswell Park Cancer Institute
~0 spots leftby Nov 2024
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