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Focused Ultrasound

calcium hydroxylapatite (Radiesse) and IFUS (Ulthera) for Loose Skin

Phase 1
Waitlist Available
Led By Natasha Mesinkovska, MD, PhD
Research Sponsored by University of California, Irvine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 weeks
Awards & highlights

Study Summary

This trial found that a combination of focused ultrasound and calcium hydroxylapatite was more effective than either treatment alone for skin laxity and volume restoration in the lower thighs.

Eligible Conditions
  • Loose Skin

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Efficacy of combined therapy at 12 weeks
Secondary outcome measures
Efficacy of combined therapy at 24 weeks
Efficacy with Merz Aesthetic scale at 12 and 24 weeks
Patient satisfaction at 24 weeks

Trial Design

1Treatment groups
Experimental Treatment
Group I: Combined microfocused ultrasound and calcium hydroxylapatiteExperimental Treatment1 Intervention
One-time intense microfocused ultrasound with calcium hydroxylapatite injection to one anterior lower thigh with option for additional filler injection at 6 weeks, 12 weeks, and 24 weeks. Optional combined treatment of the opposite lower anterior thigh at week 24 with no further follow up.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Calcium
Not yet FDA approved

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

University of California, IrvineLead Sponsor
543 Previous Clinical Trials
1,922,981 Total Patients Enrolled
Natasha Mesinkovska, MD, PhDPrincipal InvestigatorUniversity of California, Irvine
1 Previous Clinical Trials
200 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Combined Focused Ultrasound and Calcium Hydroxylapatitie Filler for Skin Laxity and Volume Restoration
Natasha Mesinkovska 2019. "Combined Focused Ultrasound and Calcium Hydroxylapatitie Filler for Skin Laxity and Volume Restoration". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04176068.
~3 spots leftby Apr 2025
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