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Quetiapine Safety with Cocaine Use Disorder

Phase 1

Waitlist Available

Led By Domenic Ciraulo, M.D.

Research Sponsored by National Institute on Drug Abuse (NIDA)

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

Study Summary

This trial will study the safety of taking cocaine while also taking the antipsychotic drug quetiapine at different doses.

Who is the study for?

This trial is for individuals who are not currently seeking treatment but have been diagnosed with cocaine abuse or dependence as defined by the DSM-IV. Participants must understand the study and consent to its procedures. Specific details on eligibility will be provided by the study site.Check my eligibility

What is being tested?

The study aims to evaluate the safety of intravenous cocaine use in participants who are taking quetiapine, an antipsychotic medication, at three different dosage levels.See study design

What are the potential side effects?

Potential side effects may include those commonly associated with cocaine use such as increased heart rate, agitation, risk of addiction, and those related to quetiapine like drowsiness, weight gain, dry mouth, and possible changes in blood pressure.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Adverse events

pharmacokinetic assessment

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

National Institute on Drug Abuse (NIDA)Lead Sponsor

2,464 Previous Clinical Trials

2,618,581 Total Patients Enrolled

Domenic Ciraulo, M.D.Principal InvestigatorBoston University

1 Previous Clinical Trials

210 Total Patients Enrolled

Media Library

Quetiapine (Other) Clinical Trial Eligibility Overview. Trial Name: NCT00087750 — Phase 1

Cocaine Use Disorder Research Study Groups:

Cocaine Use Disorder Clinical Trial 2023: Quetiapine Highlights & Side Effects. Trial Name: NCT00087750 — Phase 1

Quetiapine (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00087750 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has this therapeutic modality been endorsed by the Food and Drug Administration?

"As it is a Phase 1 trial, the safety of this treatment has been estimated to be at level 1 due to its lack of clinical evidence in supporting both efficacy and safety."

Answered by AI

Is there an opportunity to join this experiment?

"This clinical trial is seeking 12 individuals with cocaine dependency and aged between 18 to 45. Those who meet these requirements may be eligible for participation."

Answered by AI

Is the age criterion for this research project restricted to those under 40?

"Eligibility for this trial is restricted to those aged 18-45."

Answered by AI

Are there any open opportunities for patients to take part in this research experiment?

"Clinicaltrials.gov confirms that this medical experiment is no longer actively recruiting patients, as it was first published on October 1st 2003 and last changed on January 10th 2017. However, 18 other clinical trials are accepting participants at the present moment."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Interaction Between Cocaine and Quetiapine - 1

2003. "Interaction Between Cocaine and Quetiapine - 1". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00087750.

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