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DHX for Cocaine Use Disorder

Phase 1
Waitlist Available
Led By Walter Ling, M.D.
Research Sponsored by National Institute on Drug Abuse (NIDA)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
M/F, ages 21-50
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Study Summary

This trial looks at the effects of a DHX on cocaine's safety and how it changes the experience.

Who is the study for?
This trial is for men and women aged 21-50 who are diagnosed with cocaine dependence according to DSM-IV criteria. Participants must consent to the study's terms. Those with a history of seizures, pregnant or nursing women, acute hepatitis, psychiatric disorders needing medication, or dependence on alcohol/sedatives cannot join.Check my eligibility
What is being tested?
The study is testing dihydrexidine (DHX), a drug that may affect how the body reacts to cocaine. It looks at safety and how DHX changes the way people feel and respond physically when they receive an infusion of cocaine.See study design
What are the potential side effects?
Possible side effects include reactions related to DHX or its interaction with cocaine which could alter heart rate, blood pressure, mood states, and potentially lead to other unspecified physiological changes.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 21 and 50 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Characterization of study population
Clinical physiological response to cocaine challen
Degree of drug craving
+7 more

Find a Location

Who is running the clinical trial?

National Institute on Drug Abuse (NIDA)Lead Sponsor
2,464 Previous Clinical Trials
2,618,593 Total Patients Enrolled
Walter Ling, M.D.Principal InvestigatorFriends Research Institute, Inc.
38 Previous Clinical Trials
4,118 Total Patients Enrolled

Media Library

Cocaine (Other) Clinical Trial Eligibility Overview. Trial Name: NCT00000348 — Phase 1
Cocaine Use Disorder Research Study Groups:
Cocaine Use Disorder Clinical Trial 2023: Cocaine Highlights & Side Effects. Trial Name: NCT00000348 — Phase 1
Cocaine (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00000348 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How perilous is this treatment for human health?

"As limited data exists on the safety and efficacy of this treatment, our team has accorded it a score of 1."

Answered by AI

Is eligibility for this study limited to those under sixty years of age?

"According to the requirements of this clinical trial, participants must be under 50 years old and above 21."

Answered by AI

Who would be an appropriate candidate for this research endeavor?

"To qualify for this cocaine abuse trial, applicants must be between 21 and 50 years of age. Right now, approximately 0 prospective participants are in the process of being accepted."

Answered by AI

Who else is applying?

What site did they apply to?
Friends Research Institute
What portion of applicants met pre-screening criteria?
Met criteria

Why did patients apply to this trial?

Hopefully this clinical trial will shed some light on my addiction.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Infusion Laboratory: Protocol 4 (Dihydrexidine) - 13
2024. "Infusion Laboratory: Protocol 4 (Dihydrexidine) - 13". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00000348.
~0 spots leftby Apr 2025
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