Treatment for Cocaine Abuse

Phase-Based Estimates
1
Effectiveness
1
Safety
Friends Research Institute, Los Angeles, CA
Cocaine Abuse
Eligibility
18 - 65
All Sexes
Eligible conditions
Cocaine Abuse

Study Summary

This study is evaluating whether a drug that blocks dopamine receptors can reduce the effects of cocaine.

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Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 10 primary outcomes in patients with Cocaine Abuse. Measurement will happen over the course of .

Characterization of study population
Clinical physiological response to cocaine challen
Degree of drug craving
Degree to which study medication influences change
Evidence of change in neurophysiology and brain ac
Evidence of change in subjective responses to coca
Frequency and intensity of drug use and sexual beh
History, incidence and amount of drug use
Population incidence of symptoms of depression, po
Type and severity of stimulant withdrawal symptoms

Trial Safety

Safety Estimate

1 of 3

Trial Design

1 Treatment Groups

Control

This trial involves 1 different treatment groups

This trial involves a single treatment. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.

ControlNo treatment in the control group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: up to 5 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly up to 5 years for reporting.

Closest Location

Friends Research Institute - Los Angeles, CA

Eligibility Criteria

This trial is for patients born any sex between 18 and 65 years old. There is one eligibility criterion to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
M/F, ages 21-50. Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the study and sign informed consent.

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can cocaine abuse be cured?

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Cocaine abuse can be easily controlled when there is an appropriate treatment approach in both the adolescent and adolescent-to-adult (ET) period of abuse that takes place among the poorest urban youth. With help from their teachers, teachers can assist in identifying and intervening with these youth.

Unverified Answer

What causes cocaine abuse?

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The prevalence of cocaine use is increased markedly by recent cocaine use. There are many factors contributing to cocaine use; however, its use is strongly influenced by social and environmental factors. There are also many possible causes of cocaine abuse, but more research is needed to fully identify these causes.

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What are common treatments for cocaine abuse?

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Cocaine is typically prescribed to medical-dependence patients as a means to reduce cravings and/or to lessen symptoms of withdrawal. The National Council on Drug Abuse in 1990 recommended that physicians take medical-dependence patients off of catecholamine-reuptake inhibitors (such as phenelzine) and benzodiazepines with the goal of preventing relapses.

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What are the signs of cocaine abuse?

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This article discusses the signs and symptoms of cocaine abuse, including nasal congestion, itching, nausea, vomiting diarrhea, constipation, insomnia, euphoria and anxiety. It also discusses cocaine's effects on the brain and how it destroys brain neurons. Signs of cocaine abuse include tachycardia, blood pressure, sweating, and elevated cortisol levels.

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How many people get cocaine abuse a year in the United States?

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Approximately 5.3 million people per year get cocaine abuse while 2.7 million people per year get cocaine abuse. The prevalence of cocaine abuse is the highest in the Northern states and in African Americans. The highest rate of cocaine abuse in the Northern states is also similar in whites. In conclusion, cocaine abuse is a major problem nationwide.

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What is cocaine abuse?

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Cocaine abuse is one of the fastest growing problems of our society, and a new generation of cocaine addicts is being nurtured and grown. The social problems these addicts encounter can have a major impact on our society and on their families. We urge our government to intervene in efforts to reduce cocaine use in our society, and to assist individuals afflicted with the problems of cocaine abuse with the financial, social, psychological, and medical means needed to change their habits.

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What is treatment?

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In order to provide the best and most cost-effective treatment for drug abusers, clinicians need to know how to maximize both the use and the quality of treatment for each patient.

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Has treatment proven to be more effective than a placebo?

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The findings of this review suggest that there does not appear to be a benefit of antidepressant treatment over placebo. However, there is some evidence that psychodynamic treatments are more effective than medication in the treatment of cocaine dependence. Further studies are required to assess whether psychopharmacological and psychodynamic therapies are equally effective in the clinical management of cocaine dependence. There is significant evidence that methadone maintenance treatment is the most effective of the reviewed treatments.

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Is treatment typically used in combination with any other treatments?

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A significant proportion of drug abusers receiving treatment (63.9%) were enrolled in a combined outpatient drug-treatment program. The most prominent drugs that added to a drug-treatment program--as indicated by their use in a combined outpatient format--were prescription opioids (especially heroin), methamphetamine, amphetamine, alcohol, benzodiazepines, and cocaine. A subgroup of methadone-maintainers may be particularly vulnerable to initiating illicit drug use because of their increased rate and severity of drug misuse. This article discusses the need to treat methadone-controlled patients for drug abuse and also their high risk of proceeding to abuse prescription drugs.

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Does treatment improve quality of life for those with cocaine abuse?

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Effective recovery is a difficult task, particularly to achieve in those suffering from chronic dependency and addiction. Patients' self-reported QOL has been found to improve following initiation of appropriate addiction treatment.

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Have there been other clinical trials involving treatment?

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Recent findings of the CHF CURE trial were a disappointment to all. It is highly probably that the study was powered, with sufficient power to detect differences between treatment arms of 1.0 SD or less. In view of the poor results of CHF CURE, no further trials based on the same design are planned.

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How does treatment work?

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Individuals who were treated for cocaine use had a significantly lower risk of being reemerged in a pattern consistent with other addictive diseases in the follow-up period. There were indications that treatment might work. The type of maintenance treatment was not identified as important in these results.

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