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Cannabinoid

Smoked cannabidiol 9.7% for Cannabidiol (CMP Trial)

Phase 1
Recruiting
Led By Leslie Lundahl, PhD
Research Sponsored by Wayne State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Participants will undergo medical evaluations using medical history, physical exam, standard lab tests (complete blood chemistry, urinalysis, urine pregnancy test for females) and 12-lead ECG.
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measured at baseline; 30 and 45 minutes post-morphine; 15 minutes post cbd 0% drug; 15, 65, and 90 minutes post 9.7% cbd drug (final drug).
Awards & highlights

CMP Trial Summary

This trial will test whether combining cannabidiol with morphine will reduce pain sensitivity more than either drug alone.

Who is the study for?
This trial is for healthy adults who have smoked cigarettes or marijuana and taken opioids more than three times in their life. They must pass a psychiatric evaluation, substance use history interview, medical exams including blood tests, urinalysis, pregnancy test for females, and an ECG.Check my eligibility
What is being tested?
The study is testing how cannabidiol (CBD), a compound found in marijuana that changes its effects, interacts with morphine on pain sensitivity. Participants will take oral morphine sulfate tablets and undergo tests to measure their response to heat and pressure pain.See study design
What are the potential side effects?
Potential side effects may include typical reactions to CBD such as tiredness, diarrhea, changes in appetite/weight; and common opioid-related side effects like drowsiness, constipation, nausea/vomiting. The combination's specific side effects are being studied.

CMP Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am willing to undergo medical evaluations including blood tests, urine tests, and an ECG.

CMP Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measured at baseline only.
This trial's timeline: 3 weeks for screening, Varies for treatment, and measured at baseline only. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
CHANGE: PAIN THRESHOLD AND TOLERANCE Pain responses to a range of heat, cold and mechanical pressure stimuli
Secondary outcome measures
SAFETY & INDICES OF ABUSE LIABILITY: Brief Pain Inventory
SAFETY & INDICES OF ABUSE LIABILITY: Drug Effect
SAFETY & INDICES OF ABUSE LIABILITY: Drug Symptoms
+8 more

CMP Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Smoked cannabidiol 9.7%Active Control2 Interventions
Group II: Smoked cannabidiol 0%Placebo Group2 Interventions

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Wayne State UniversityLead Sponsor
307 Previous Clinical Trials
108,739 Total Patients Enrolled
Leslie Lundahl, PhDPrincipal Investigator - Wayne State University
Wayne State University
5 Previous Clinical Trials
315 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~5 spots leftby Jan 2025