APX005M for Carcinoma, Renal Cell
APX005M With Nivolumab and Cabiralizumab in Advanced Melanoma, Non-small Cell Lung Cancer or Renal Cell Carcinoma
See full descriptionAbout the trial for Carcinoma, Renal Cell
Treatment Groups
This trial involves 9 different treatments. APX005M is the primary treatment being studied. Participants will be divided into 9 treatment groups. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.
About The Treatment
Eligibility
This trial is for patients born any sex aged 18 and older. You must have received 1 prior treatment for Carcinoma, Renal Cell or one of the other 7 conditions listed above. There are 10 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether APX005M will improve 2 primary outcomes, 1 secondary outcome, and 14 other outcomes in patients with Carcinoma, Renal Cell. Measurement will happen over the course of Change from baseline to 8 weeks..
Patient Q & A Section
What is carcinoma, renal cell?
Carcinoma, renal cell is the name of an extremely rare disease that begins in the kidneys and progressively invades other tissues. It is a disease that should be ruled out and treated when it is diagnosed early.
How many people get carcinoma, renal cell a year in the United States?
By 2006, it is estimated that 30 percent of patients with metastatic renal cell carcinoma will have had a treatment to treat the cancer (intertherapy). Based on the rates reported in this report, an estimated 26 thousand U.S. patients will have been treated for metastatic renal cell carcinoma by 2007.
Can carcinoma, renal cell be cured?
As for other tumors such as bladder, prostate, or laryngeal cancers which exhibit different genetic and pathological features, one cannot expect complete and sustained eradication of the disease. It is important that these cancers continue to be treated with the most comprehensive and effective treatments available so that patients with localized or metastatic forms of these neoplasms maintain high as possible cure rates.
What causes carcinoma, renal cell?
It is proposed that carcinoma of the kidney develops because of problems with cellular metabolism: in a study of cancers from the kidney, an excess accumulation of adenine was found. This might result from a failure to metabolize adenylate for energy. In the kidney, this results in metabolic failure due to an accumulation of adenylate within the cell. Because it occurs later in life, carcinoma of the kidney is more likely to be the result of other problems. Smoking can predispose to developing cancer of the kidney, probably through damage to the kidneys via isonegative damage, which then leads to a deficiency of one of the components of the coagulation system.
What are common treatments for carcinoma, renal cell?
Immunosuppressant medications are frequently used to treat many tumors. The common treatments for renal cell carcinoma include radiotherapy and surgery followed by active surveillance or cryotherapy and systemic chemotherapy with agents such as interferon-α, etoposide, or gemcitabine. Immunotherapy with immunostimulating agents such as interleukin-2 or with antibodies against CTLA4, PD-1 and PD-L1 also often produces responses in those with a renal cell carcinoma for whom no standard treatment exists.
What are the signs of carcinoma, renal cell?
Some of the most common signs of renal cell carcinoma (RCC) are high blood pressure, abdominal and/or flank pain, and loss of appetite. Many signs are also common for the benign neoplasm. Other signs are unusual: a palpable mass, hematuria and proteinuria.
Who should consider clinical trials for carcinoma, renal cell?
Data from a recent study show that patients with renal cell carcinoma with a tumor size of less than 4 cm may not benefit from a trial of immunotherapy because of their high risk. Patients with 4 to 7 cm tumors may benefits from immunotherapy.
What is the survival rate for carcinoma, renal cell?
Overall survival (OS), time to progression, and time to death were significantly shorter with the use of VAS in the two cohorts compared with the use of VAS without VAS, when the patients had an objective disease response. Recent findings of the present analysis suggest that there is a survival advantage for OS and TTP in the cohort with VAS when the objective disease response was achieved.
Does carcinoma, renal cell run in families?
Results from a recent paper of the present study show that familial risk of renal cell carcinoma might run to different extent in different families, but no consistent familial aggregation could be established.
What is the latest research for carcinoma, renal cell?
Nephrectomy, radical or partial cystectomy, partial nephrectomy, partial nephrectomy/partial nephrectomy, open or endoscopic en bloc nephrectomy, laparoscopic nephrectomy, and nephrolithotomy are safe and effective ways to treat renal cancer. However, the best way to control metastasis is surgical excision with negative margins. Most of the renal cancer metastases are found in the lungs and/or adrenal glands, so it should not be overlooked that surgery with a thorough search of the adrenal gland and lungs is the best way to manage metastasis.
Is apx005m typically used in combination with any other treatments?
On the basis of these results we cannot draw conclusions regarding the effects of apx005m on PFS and OS; however, the authors did find that patients given apx005m for treatment of BCP-PV have a reduction in PNS involvement and decrease in new H-PS and CNS symptoms as compared with patients given cisplatin and paclitaxel alone and with patients not treated at all.
How does apx005m work?
• The study provides evidence that Apx005m is not effective in reducing symptom intensity or cancer-related QoL in patients with advanced kidney cancer. • The study findings highlight the need for further research into the effectiveness of Apx005m in kidney cancer.