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Viral Therapy for Liver Cancer
Study Summary
This trial is studying a new virus that has been genetically engineered to produce interferon beta, which may help to treat patients with liver cancer or other solid tumors that have spread to other parts of the body and are not responding to treatment.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Media Library
- Most of my liver cancer is inside my liver.My cancer is confirmed and has skin lesions, and standard treatments haven't worked or caused side effects.I am not receiving any other cancer treatments.My liver function is classified as Child Pugh A or B7, and I can have an injection procedure if I have fluid in my abdomen.I haven't had any cancer treatment in the last 4 weeks.I am not receiving any other cancer treatments while on ARM A.I have not used any corticosteroids in the last 28 days.I have not had radioembolization or TACE in the last 84 days.I have had a bone marrow or organ transplant.I have not used any corticosteroids in the last 28 days.My liver cancer hasn't responded to or I can't tolerate sorafenib, or my advanced cancer mainly affects the liver and has worsened despite treatment.I am fully active or restricted in physically strenuous activity but can do light work.Less than 25% of my liver is affected by the disease.I am willing to go back to Mayo Clinic in Arizona for my follow-up.I am fully active or restricted in physically strenuous activity but can do light work.My liver function is classified as Child-Pugh A.My liver cancer affects less than 25% of my liver.I have had a bone marrow or organ transplant.Surgery or liver transplant is a better option for me than ARM A treatment.I do not have any infections that are currently uncontrolled.I am HIV positive.I haven't had any cancer treatment in the last 4 weeks.I am a candidate for liver surgery or transplantation instead of other treatments.I have not had radioembolization or TACE in the last 84 days.I can sign and understand the consent form.
- Group 1: Arm A (viral therapy in single tumor location)
- Group 2: Arm B (viral therapy in multiple locations)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is there an intake process currently in place for this research endeavor?
"Per the clinicaltrials.gov platform, this medical trial is not currently enrolling any individuals; however it was first posted on August 3rd 2012 and last updated October 7th 2022. Currently, there are 2680 other trials actively recruiting patients to participate in research studies."
Could you outline any previous investigations into the therapeutic effects of Pharmacological Study?
"At present, 5 experiments on Pharmacological Study are in progress with 1 of them being tested at the late-stage. The majority of these tests take place in Scottsdale, Arizona; however there are 133 other places that offer trials for this same medication."
Has the Pharmacological Study been given approval from the FDA?
"We have assigned a score of 1 to the safety profile for this pharmacological study, as it is only at Phase 1 and thus has limited evidence showing its efficacy or risk."
What is the current sample size of this research endeavor?
"This clinical trial has concluded its recruitment process, having started on August 3rd 2012 and ending October 7th 2022. Nonetheless, there are currently 2675 trials for liver carcinoma that still need participants as well 5 Pharmacological Studies welcoming volunteers."
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