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ALRN-6924 Dose plus TAC for Prevention of Chemotherapy-induced Myelosuppression

Phase 1
Waitlist Available
Research Sponsored by Aileron Therapeutics, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up cycle 1 (each cycle is 21 days)
Awards & highlights

Study Summary

This trial is testing a new drug to help protect healthy cells from chemotherapy damage, reducing side effects.

Eligible Conditions
  • Prevention of Chemotherapy-induced Myelosuppression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~cycle 1 (each cycle is 21 days)
This trial's timeline: 3 weeks for screening, Varies for treatment, and cycle 1 (each cycle is 21 days) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Bone Marrow
Safety and tolerability of ALRN-6924 in combination with TAC chemotherapy
Secondary outcome measures
Neutropenia
Alopecia
Anemia
+11 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: ALRN-6924 Dose plus TACExperimental Treatment2 Interventions
ALRN-6924 plus Docetaxel, Doxorubicin, and Cyclophosphamide (TAC)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
ALRN-6924
2018
Completed Phase 2
~230

Find a Location

Who is running the clinical trial?

Aileron Therapeutics, Inc.Lead Sponsor
5 Previous Clinical Trials
293 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What potential dangers are associated with ALRN-6924 Dose plus TAC?

"Due to the limited data available on ALRN-6924 Dose plus TAC, our team at Power gave it a safety score of 1. This is reflective of its status as a Phase 1 trial without any clinical evidence for efficacy or security."

Answered by AI

What are the desired outcomes of this research endeavor?

"Aileron Therapeutics, Inc., the trial sponsor in question, has outlined several objectives for this study. Over a period of 24 weeks, their primary aim is to assess ALRN-6924's ability to protect bone marrow from toxicities. Secondary outcomes include an evaluation of the drug's pharmacokinetics (PK), how many platelet transfusions are needed during each cycle and over all cycles combined, as well as its chemoprotective effects on neutropenia across multiple treatment cycles."

Answered by AI

Are there any vacancies available for this clinical experiment?

"The clinicaltrial.gov site indicates that this medical trial is in progress and actively recruiting patients. The investigation was posted on November 1st 2022, with updates taking place as recently as the 16th of the same month."

Answered by AI

What is the upper limit of participants in this experiment?

"Affirmative. Clinicaltrials.gov reveals that the trial, first posted on November 1st 2022 and last amended on the 16th of the same month is actively recruiting participants for enrollment; 26 individuals need to be recruited from 5 distinct sites."

Answered by AI

How many centers are responsible for administering this clinical trial?

"Presently, this clinical trial is inviting participants to join from 5 different medical centres. Canton, Gettysburg and Huntersville are amongst the locations where recruitment is taking place. As such it would be sensible for applicants to choose a clinic closest them in order to reduce their travelling requirements should they decide to participate."

Answered by AI
~3 spots leftby Apr 2025