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18F-MK-6240 for Alzheimer's Disease

Phase 1
Waitlist Available
Led By Adam M Brickman, Ph.D.
Research Sponsored by Adam Brickman
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Study Summary

This trial looks at whether tau positron emission tomography (PET) imaging can show differences in tau pathology across racial/ethnic groups and how this relates to cognition and cerebrovascular disease.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Amyloid Positivity (Aβ+) for 18F-Florbetaben
Regional SUVR value for 18F-MK-6240

Trial Design

1Treatment groups
Experimental Treatment
Group I: Offspring CohortExperimental Treatment2 Interventions
Racially/ethnically diverse subjects with or without a positive family history of Alzheimer's disease (AD) will have one PET scan with 18F-MK-6240 over a 30 to 60-minute scanning period, and one PET scan with 18F-Florbetaben over a 20-minute scanning period.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
18F-MK-6240
2019
Completed Phase 2
~220
Florbetaben (18F)
FDA approved

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

National Institute on Aging (NIA)NIH
1,667 Previous Clinical Trials
28,005,048 Total Patients Enrolled
Adam BrickmanLead Sponsor
Adam M Brickman, Ph.D.Principal InvestigatorColumbia University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are applications still open for this research study?

"According to clinicaltrials.gov, this study has paused its recruitment process as of October 7th 2022; however, there are currently 553 other trials actively seeking participants. Initially posted on March 22nd 2019, the trial is not presently in need of additional volunteers."

Answered by AI

Can you provide a comprehensive overview of all experiments done using 18F-MK-6240?

"As of now, 7 clinical trials for 18F-MK-6240 are underway with none in their third phase. The bulk of these studies take place in Philadelphia, Pennsylvania yet 9 other sites across the country have also joined this medical research effort."

Answered by AI

What is the aggregate number of participants involved in this clinical experiment?

"At the moment, this research is not recruiting any further participants. The trial was initially posted on March 22nd 2019 and recently updated on October 7th 2022. Should you be looking for other studies to join, there are 546 trials in search of individuals with Alzheimer's disease while another 7 require enrollees for 18F-MK-6240 treatments."

Answered by AI

Is this an inaugural trial exploring the efficacy of this therapy?

"Since 2010, 18F-MK-6240 has been explored through clinical trials. The initial attempt was carried out in 2010 and sponsored by Bayer. This trial included 161 participants and resulted in the drug being granted N/A approval. Presently, there are 7 active studies taking place across 3 cities and 2 countries involving this compound."

Answered by AI

What are the criteria for individuals to be enrolled in this research endeavor?

"The requirements to join this investigation are a diagnosis of Alzheimer's disease and being within the age range between 35-85. Approximately 150 individuals will be included in the trial."

Answered by AI

Are individuals aged over 40 eligible for this trial?

"To qualify for this trial, individuals must be between 35 and 85 years of age. Those younger than 18 have 23 trials available to them, while those over 65 can choose from 543 options."

Answered by AI

Has the FDA greenlit 18F-MK-6240 for medical use?

"Due to the lack of data supporting 18F-MK-6240's efficacy and safety, our team at Power has assigned it an estimated rating of 1."

Answered by AI
~24 spots leftby Apr 2025