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benzocaine for Obesity

Phase 1
Waitlist Available
Led By Naji N Abumrad, MD
Research Sponsored by Vanderbilt University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 hours
Awards & highlights

Study Summary

This trial is testing if a new diet can help people with obesity by regulating their metabolism hormone secretion and nutrient metabolism.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Gastrointestinal Hormones
Glucose and Free Fatty Acids
Pancreatic Hormones
Secondary outcome measures
Fat Metabolism
Glucose Metabolism
Other outcome measures
Appetite, Hunger, and GI symptoms

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: benzocaineActive Control1 Intervention
0.5% benzocaine solution in saline/hydrochloric acid administered by intraduodenal infusion one time (6 ml bolus followed by 75 ml/hour for 105 minutes)
Group II: placeboPlacebo Group1 Intervention
Placebo (saline) solution administered by intraduodenal infusion one time (6 ml bolus followed by 75 ml/hour for 105 minutes)

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Vanderbilt University Medical CenterLead Sponsor
855 Previous Clinical Trials
672,165 Total Patients Enrolled
35 Trials studying Obesity
6,854 Patients Enrolled for Obesity
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,352 Previous Clinical Trials
4,315,115 Total Patients Enrolled
446 Trials studying Obesity
588,911 Patients Enrolled for Obesity
Naji N Abumrad, MDPrincipal InvestigatorVanderbilt University Medical Center
5 Previous Clinical Trials
142 Total Patients Enrolled
5 Trials studying Obesity
142 Patients Enrolled for Obesity

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To what demographic does this research project cater?

"To be eligible to participate in this trial, patients must meet the criteria of having obesity and being within the age range of 20-50. A total pool of 45 individuals is required for completion."

Answered by AI

In what cases is benzocaine commonly prescribed?

"Benzocaine is the most commonly prescribed medication for laryngitis and can be administered to treat other ailments, such as secondary bacterial infection caused by tonsillectomy, ulceration of the gastrointestinal tract, or persistent vomiting."

Answered by AI

Is the usage of benzocaine sanctioned by the FDA?

"Our team at Power has ranked benzocaine's safety rating a 1 due to the limited evidence provided in Phase 1 clinical trials."

Answered by AI

Is enrollment open to those aged eighty or above in this research experiment?

"To qualify for participation in the study, prospective patients must fall between 20 and 50 years old."

Answered by AI

How many individuals have joined the experiment to date?

"Presently, this research is not accepting applicants. Initially posted on September 1st 2015 and last edited March 29th 2022, if you are searching for other medical trials there are currently 956 studies actively enrolling participants with obesity as well as two clinical trials researching benzocaine that have open enrolment."

Answered by AI

Have any previous investigations examined the effects of benzocaine?

"Presently, there are 2 ongoing trials for benzocaine with none of them in the last phase. While most studies occur in Nashville, Tennessee, two other locations also run investigations into this drug."

Answered by AI

Are there any available slots to join this clinical trial?

"The trial closed on March 29th 2022 and is no longer actively recruiting patients. Nonetheless, 956 studies related to obesity are still open for enrolment as well as 2 trials studying the effects of benzocaine."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Role of the Foregut in Nutrient Metabolism in Lean and Obese Humans
Naji Abumrad 2015. "Role of the Foregut in Nutrient Metabolism in Lean and Obese Humans". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02537314.
~3 spots leftby Apr 2025
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