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Antisense Inhibitor

ION547 for Healthy Subjects

Phase 1
Waitlist Available
Research Sponsored by Ionis Pharmaceuticals, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to day 232
Awards & highlights

Study Summary

This study is evaluating whether a drug that blocks a gene can be safely given to healthy people.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to day 232
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to day 232 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
AUCt: Area Under the Plasma Concentration-time Curve From Time Zero to Time t for ION547
Change from Baseline in FXII Activity Levels
Change from Baseline in FXII Antigen Levels
+4 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: ION547Experimental Treatment1 Intervention
Ascending single multiple doses of ION547 will be administered by SC injection.
Group II: PlaceboPlacebo Group1 Intervention
Ascending single multiple doses of ION547-matching placebo will be administered by SC injection.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
ION547
2021
Completed Phase 1
~50

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Ionis Pharmaceuticals, Inc.Lead Sponsor
146 Previous Clinical Trials
15,234 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of ION547
2021. "A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of ION547". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04934891.
~12 spots leftby Apr 2025
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