Vaporized THC, limonene, or THC and limonene for D-Limonene and THC Pharmacodynamics

Johns Hopkins Behavioral Pharmacology Research Unit, Baltimore, MD
D-Limonene and THC PharmacodynamicsVaporized THC, limonene, or THC and limonene - Drug
Eligibility
18 - 55
All Sexes
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Study Summary

This trial will study how d-limonene and THC affect the body when inhaled.

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase 1

Similar Trials

1
Oral administration of 2.5 mg THC
1
Active THC
1
THC

Study Objectives

1 Primary · 3 Secondary · Reporting Duration: 6 hours

6 hours
Change in Heart Rate
Difficulty in Performing Routine Tasks as assessed the Drug Effect Questionnaire (DEQ)
Level of Anxiety as assessed by the Drug Effect Questionnaire (DEQ)
Level of Unpleasant Effect as assessed by the Drug Effect Questionnaire (DEQ)

Trial Safety

Phase-Based Safety

1 of 3

Similar Trials

1
Oral administration of 2.5 mg THC
1
Active THC
1
THC

Trial Design

9 Treatment Groups

Vaporized low d-limonene
1 of 9
Vaporized high d-limonene
1 of 9
Low THC and high d-limonene
1 of 9
Vaporized high THC
1 of 9
Low THC and low d-limonene
1 of 9
Vaporized low THC
1 of 9
High THC and low d-limonene
1 of 9
High THC and high d-limonene
1 of 9
Placebo
1 of 9

Experimental Treatment

Non-Treatment Group

20 Total Participants · 9 Treatment Groups

Primary Treatment: Vaporized THC, limonene, or THC and limonene · Has Placebo Group · Phase 1

Vaporized low d-limonene
Drug
Experimental Group · 1 Intervention: Vaporized THC, limonene, or THC and limonene · Intervention Types: Drug
Vaporized high d-limonene
Drug
Experimental Group · 1 Intervention: Vaporized THC, limonene, or THC and limonene · Intervention Types: Drug
Low THC and high d-limonene
Drug
Experimental Group · 1 Intervention: Vaporized THC, limonene, or THC and limonene · Intervention Types: Drug
Vaporized high THC
Drug
Experimental Group · 1 Intervention: Vaporized THC, limonene, or THC and limonene · Intervention Types: Drug
Low THC and low d-limonene
Drug
Experimental Group · 1 Intervention: Vaporized THC, limonene, or THC and limonene · Intervention Types: Drug
Vaporized low THC
Drug
Experimental Group · 1 Intervention: Vaporized THC, limonene, or THC and limonene · Intervention Types: Drug
High THC and low d-limonene
Drug
Experimental Group · 1 Intervention: Vaporized THC, limonene, or THC and limonene · Intervention Types: Drug
High THC and high d-limonene
Drug
Experimental Group · 1 Intervention: Vaporized THC, limonene, or THC and limonene · Intervention Types: Drug
Placebo
Drug
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Drug

Trial Logistics

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 6 hours

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor
2,115 Previous Clinical Trials
32,578,749 Total Patients Enrolled
National Institute on Drug Abuse (NIDA)NIH
2,302 Previous Clinical Trials
2,022,516 Total Patients Enrolled
Ryan Vandrey, PhDPrincipal InvestigatorJohns Hopkins University
11 Previous Clinical Trials
487 Total Patients Enrolled

Eligibility Criteria

Age 18 - 55 · All Participants · 2 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have felt anxious after using cannabis before.
Your body mass index (BMI) falls within the range of 18 to 36 kg/m2.
References

Frequently Asked Questions

What is the enrollment capacity of this research endeavor?

"Affirmative. Clinicaltrials.gov hosts records that indicate this medical trial is currently recruiting participants, which began on April 1st 2019 and was later updated in September 2022. The research endeavour seeks to enrol 20 individuals at one centre." - Anonymous Online Contributor

Unverified Answer

Are there any open enrollment opportunities for this clinical trial?

"According to the information present on clinicaltrials.gov, this trial is still searching for participants. This project was posted online on April 1st 2019 and underwent its latest revision on September 7th 2022." - Anonymous Online Contributor

Unverified Answer

Are there any FDA-sanctioned applications for vaporized THC, limonene, or their combination?

"We have assigned Vaporized THC, limonene, or a combination thereof a score of 1 on our safety scale as this is an early stage trial and there exists limited evidence supporting its efficacy and security." - Anonymous Online Contributor

Unverified Answer

Does my medical profile qualify me for participation in this experiment?

"This trial is currently looking for 20 willing participants, aged between 18 and 55 years old, who are already taking dronabinol. Moreover, these individuals must be in sound physical health (as certified by a general medical exam), have an acceptable BMI range of 18 to 36 kg/m2, show no allergies towards the components used to make vapor (THC and d-Limonene) , test negative for drugs other than cannabis at both screening visit and clinic admission, as well as not presenting any breath alcohol readings." - Anonymous Online Contributor

Unverified Answer

Is elderly participation possible in this clinical experiment?

"The age bracket for participation in this research is between 18 and 55 years old." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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