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Terpene

Vaporized THC, limonene, or THC and limonene for D-Limonene and THC Pharmacodynamics

Phase 1
Waitlist Available
Led By Ryan Vandrey, PhD
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0-6 hours
Awards & highlights

Study Summary

This trial will study how d-limonene and THC affect the body when inhaled.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0-6 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0-6 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mean Peak Change From Baseline Anxiety as Assessed by the Drug Effect Questionnaire (DEQ)
Secondary outcome measures
Mean Peak Change From Baseline Heart Rate
Mean Peak Change From Baseline Paranoid as Assessed by the Drug Effect Questionnaire (DEQ)
Mean Peak Change From Baseline Subjective "Heart Racing" as Assessed by the Drug Effect Questionnaire (DEQ)

Side effects data

From 2023 Phase 1 trial • 53 Patients • NCT03609853
11%
Tachycardia
100%
80%
60%
40%
20%
0%
Study treatment Arm
Low THC and Low D-limonene
Vaporized Low D-limonene
Vaporized Low THC
Low THC and High D-limonene
Placebo
Vaporized High THC
High THC and Low D-limonene
High THC and High D-limonene
High THC and 15mg D-limonene
Vaporized High D-limonene

Trial Design

10Treatment groups
Experimental Treatment
Placebo Group
Group I: Vaporized low d-limoneneExperimental Treatment1 Intervention
1mg of d-limonene
Group II: Vaporized low THCExperimental Treatment1 Intervention
15mg of pure THC
Group III: Vaporized high d-limoneneExperimental Treatment1 Intervention
5mg of d-limonene
Group IV: Vaporized high THCExperimental Treatment1 Intervention
30mg of pure THC
Group V: Low THC and low d-limoneneExperimental Treatment1 Intervention
15mg of THC paired with 1mg of d-limonene
Group VI: Low THC and high d-limoneneExperimental Treatment1 Intervention
15mg of THC paired with 5mg of d-limonene
Group VII: High THC and low d-limoneneExperimental Treatment1 Intervention
30mg of THC paired with 1mg of d-limonene
Group VIII: High THC and high d-limoneneExperimental Treatment1 Intervention
30mg of THC paired with 5mg of d-limonene
Group IX: High THC and 15mg d-limoneneExperimental Treatment1 Intervention
30mg of THC paired with 15mg of d-limonene
Group X: PlaceboPlacebo Group1 Intervention
Placebo (5mL distilled water)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Vaporized THC, limonene, or THC and limonene
2019
Completed Phase 1
~60

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor
2,260 Previous Clinical Trials
14,820,727 Total Patients Enrolled
National Institute on Drug Abuse (NIDA)NIH
2,467 Previous Clinical Trials
2,619,070 Total Patients Enrolled
Ryan Vandrey, PhDPrincipal InvestigatorJohns Hopkins University
12 Previous Clinical Trials
532 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the enrollment capacity of this research endeavor?

"Affirmative. Clinicaltrials.gov hosts records that indicate this medical trial is currently recruiting participants, which began on April 1st 2019 and was later updated in September 2022. The research endeavour seeks to enrol 20 individuals at one centre."

Answered by AI

Are there any open enrollment opportunities for this clinical trial?

"According to the information present on clinicaltrials.gov, this trial is still searching for participants. This project was posted online on April 1st 2019 and underwent its latest revision on September 7th 2022."

Answered by AI

Are there any FDA-sanctioned applications for vaporized THC, limonene, or their combination?

"We have assigned Vaporized THC, limonene, or a combination thereof a score of 1 on our safety scale as this is an early stage trial and there exists limited evidence supporting its efficacy and security."

Answered by AI

Does my medical profile qualify me for participation in this experiment?

"This trial is currently looking for 20 willing participants, aged between 18 and 55 years old, who are already taking dronabinol. Moreover, these individuals must be in sound physical health (as certified by a general medical exam), have an acceptable BMI range of 18 to 36 kg/m2, show no allergies towards the components used to make vapor (THC and d-Limonene) , test negative for drugs other than cannabis at both screening visit and clinic admission, as well as not presenting any breath alcohol readings."

Answered by AI

Is elderly participation possible in this clinical experiment?

"The age bracket for participation in this research is between 18 and 55 years old."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Behavioral Pharmacology of THC and D-limonene
2019. "Behavioral Pharmacology of THC and D-limonene". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03609853.
~9 spots leftby Apr 2025
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