NPWT vs Conventional Dressings for Hip Surgery Recovery
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests two types of bandages to determine which aids recovery better after hip surgery. One group will use standard sterile dressings, while the other will use a special bandage called negative pressure wound therapy (NPWT), which might reduce wound issues and infections. Researchers aim to discover if NPWT results in fewer complications and less need for additional surgeries. This trial suits individuals recovering from specific hip surgeries, such as revision total hip arthroplasty (THA) for repairing loose parts or infections, who can have their incision closed without extra skin or muscle work. Participants must be willing to try one of the bandages and attend follow-up visits. As a Phase 1 trial, the research focuses on understanding how the treatment works in people, offering participants the chance to be among the first to receive this innovative therapy.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that negative pressure wound therapy (NPWT) is safe for hip surgery recovery?
Research has shown that negative pressure wound therapy (NPWT) is safe for hip revision surgeries. One study found that NPWT did not cause any problems in these surgeries. Another study found that NPWT helped lower the risk of deep infections after bone surgery. However, some patients experienced blisters while using NPWT.
Overall, NPWT appears to reduce the risk of infection and other wound issues after surgery. It is important to note that minor skin reactions, such as blisters, can occur.12345Why are researchers excited about this trial's treatments?
Researchers are excited about negative pressure wound therapy (NPWT) for hip surgery recovery because it offers a different approach to healing compared to conventional sterile antimicrobial dressings. Unlike standard dressings like AQUACEL, which passively cover the wound, NPWT actively uses suction to promote faster healing and reduce infection risk. This method can potentially lead to more efficient recovery times and better outcomes for patients, making it a promising option in surgical care.
What evidence suggests that NPWT is effective for hip surgery recovery?
Research has shown that Negative Pressure Wound Therapy (NPWT), one of the treatments studied in this trial, can help reduce wound complications after hip surgery. Studies have found that NPWT keeps wounds dry, lowering the risk of infection in 76% of patients. It also results in fewer infections at the surgery site and fewer repeat surgeries compared to regular dressings. This method works by gently removing fluids from the wound, aiding in healing. Overall, NPWT has improved recovery after hip and knee surgeries by reducing the chance of infection and other complications. Participants in this trial will receive either NPWT or Sterile Antimicrobial Dressings, the current hospital standard, to compare their effectiveness in recovery.23678
Who Is on the Research Team?
Denis Nam, MD, MSc
Principal Investigator
Rush University Medical Center
Are You a Good Fit for This Trial?
This trial is for adults over 18 who need a revision of their hip replacement surgery. It's open to those with loose components, bone loss, or fractures needing component changes, and infections treated by various methods. Participants must be able to close the wound normally without grafts and agree to follow-up visits.Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo revision total hip arthroplasty with either NPWT or sterile dressings applied intra-operatively
Follow-up
Participants are monitored for wound complications, infections, and reoperations
What Are the Treatments Tested in This Trial?
Interventions
- Negative Pressure Wound Therapy (NPWT)
- Revision THA
- Sterile Antimicrobial Dressings
Trial Overview
The study compares Negative Pressure Wound Therapy (NPWT) with standard sterile dressings in preventing complications after hip revision surgeries. The goal is to see if NPWT reduces problems like infections and the need for more surgeries better than regular dressings.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Experimental group. Negative pressure wound therapy bandage applied intra-operatively by a physician on the treatment team. The dressing will be removed after 7 days postoperatively, or if the battery power stops earlier.
Control group, current hospital standard. AQUACEL is left in place for 7 days unless it becomes saturated over 50%, which requires a premature dressing change.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Rush University Medical Center
Lead Sponsor
3M
Industry Sponsor
Dr. John Banovetz
3M
Chief Medical Officer since 2017
PhD in Inorganic Chemistry from Stanford University, Bachelor's degree in Chemistry from Hamline University
William 'Bill' Brown
3M
Chief Executive Officer
Bachelor's and Master's degrees in Mechanical Engineering from Villanova University, MBA from The Wharton School, University of Pennsylvania
Published Research Related to This Trial
Citations
Negative Pressure Wound Therapy Is Associated With ...
The flowchart illustrates the clinical outcomes after use of the NPWT for persistent wound drainage after hip arthroplasty. In 76% of patients, a dry wound was ...
The effectiveness of prophylactic closed incision negative ...
Prophylactic application of ciNPWT may be effective in reducing wound complications, PJI and reoperation post hip and knee revision arthroplasty surgery.
Comparison of Negative Pressure Wound Therapy vs. ...
Wound complications within 90 days of a revision total hip arthroplasty include: wound dehiscence, prolonged drainage for >7 days postoperatively, hematoma ...
Randomized Controlled Trial of Incisional Negative ...
Closed incision negative pressure therapy (ciNPT) is effective in reducing SSCs and surgical site infections (SSIs) in other populations.
Negative pressure wound therapy in total hip and knee ...
Conclusion: NPWT decreased the incidence of superficial surgical site infection. More blisters were noticed in patients with NPWT after total ...
INCISIONAL NEGATIVE-PRESSURE WOUND THERAPY ...
The main finding of this study was that NPWT may be safely used in revision surgeries of hip prosthesis for chronic infection, without any complications and ...
Effect of negative pressure wound therapy on the incidence ...
The results of our study indicate that the prophylactic use of NPWT reduces the incidence of deep SSIs following orthopedic trauma surgery.
Revision Arthroplasty Closed-Incision Negative-Pressure ...
Conclusion. Our findings suggest that ciNPT may decrease wound complications and SSIs in patients undergoing revision hip and knee surgery.
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.