Your session is about to expire
← Back to Search
Other
Hyperbaric Oxygen for Infections (O2B Trial)
Phase 1
Recruiting
Led By Lindell K Weaver, MD
Research Sponsored by Intermountain Health Care, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up within 30 minutes after chamber session 1
Awards & highlights
O2B Trial Summary
This trial will compare the effects of hyperbaric chamber sessions and normal pressure oxygen breathing on blood neutrophil oxidative burst and cytokine analysis.
O2B Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ within 30 minutes after chamber session 1
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~within 30 minutes after chamber session 1
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Oxidative Burst Assay
O2B Trial Design
9Treatment groups
Experimental Treatment
Active Control
Group I: Volunteers, normobaric pressureExperimental Treatment1 Intervention
Healthy volunteers will have their blood drawn before and after breathing 100% oxygen at atmospheric pressure (normobaric oxygen) for 120 minutes.
Group II: Hyperbaric chamber inside attendantsExperimental Treatment1 Intervention
Hyperbaric chamber inside attendants will have their blood drawn before, mid-session, and after their chamber exposure during their regular duty day. The hyperbaric chamber exposure will include hyperbaric air and hyperbaric oxygen components (hyperbaric air/oxygen).
Group III: Brain injury research subjectsExperimental Treatment1 Intervention
Research subjects co-enrolled in a study examining hyperbaric oxygen for post-concussive symptoms will have blood drawn before and after their first and fourth hyperbaric chamber sessions.
Group IV: Glucose tolerance testActive Control1 Intervention
Diabetic patients co-enrolled in a hyperbaric oxygen and glucose control study will have blood drawn before and after their glucose tolerance test and their first clinical hyperbaric oxygen treatment.
Group V: Diabetics with active, chronic infectionActive Control1 Intervention
Adult patients with diabetes mellitus and current antibiotic use for active infection will have blood drawn before and after their first and fourth clinical hyperbaric oxygen treatments.
Group VI: No diabetes or infectionActive Control1 Intervention
Adult patients without diabetes and not using antibiotics will have blood drawn before and after their first and fourth clinical hyperbaric oxygen treatments.
Group VII: Critically ill patients with infectionActive Control1 Intervention
Adult patients with acute, life-threatening infection for which hyperbaric oxygen is clinically indicated will have blood drawn before and after their first and fourth clinical hyperbaric oxygen treatments.
Group VIII: Carbon monoxide patientsActive Control1 Intervention
Adult patients with acute carbon monoxide poisoning will have blood drawn before and after their first clinical hyperbaric oxygen treatment.
Group IX: Volunteers, hyperbaric oxygenActive Control1 Intervention
Healthy adult volunteers will have blood drawn before and after a single hyperbaric chamber session.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Hyperbaric Oxygen
2005
Completed Phase 3
~260
Find a Location
Logistics
Participation is compensated
You will be compensated for participating in this trial.
Who is running the clinical trial?
Intermountain Health Care, Inc.Lead Sponsor
137 Previous Clinical Trials
1,963,070 Total Patients Enrolled
2 Trials studying Infections
4,050 Patients Enrolled for Infections
Lindell K Weaver, MDPrincipal InvestigatorIntermountain Health Care, Inc.
4 Previous Clinical Trials
212 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have had serious health problems in the past, such as bone or muscle diseases, heart or blood vessel problems, blood clotting disorders, cancer, high cholesterol or triglycerides, high blood pressure, diabetes, or liver/kidney issues.You are an adult between the ages of 18 and 65 who is in the intensive care unit for a serious infection that requires hyperbaric oxygen treatment.You have a long-term medical condition that is currently active.You have taken any medication or supplement, except for a basic multivitamin, within the last 30 days.You have taken vitamin C or vitamin E supplements regularly in the last year.You currently smoke cigarettes or use other tobacco products.You are an adult between the ages of 18 and 65 and need to undergo at least 4 hyperbaric oxygen sessions for certain chronic conditions like crush injury, poor blood flow in the limbs, or damage from radiation.You have received hyperbaric oxygen treatment within the last month.You are pregnant.You have a known or suspected bacterial or viral infection.You cannot participate if you are already enrolled in a study for brain injuries.
Research Study Groups:
This trial has the following groups:- Group 1: Brain injury research subjects
- Group 2: Volunteers, normobaric pressure
- Group 3: Glucose tolerance test
- Group 4: Diabetics with active, chronic infection
- Group 5: No diabetes or infection
- Group 6: Critically ill patients with infection
- Group 7: Carbon monoxide patients
- Group 8: Hyperbaric chamber inside attendants
- Group 9: Volunteers, hyperbaric oxygen
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Could I be accepted into this medical investigation?
"To be eligible for the study, participants must have contracted the infection and fall within 18-65 years old. Approximately 40 patients are required to fill out the necessary enrolment forms."
Answered by AI
Are new participants currently being welcomed for this clinical trial?
"This trial is still recruiting participants according to clinicaltrials.gov, and it was initially advertised on April 1st 2015 with an amendment made in August 2nd 2022."
Answered by AI
Does this research project admit participants who have exceeded the age of twenty?
"This clinical trial has established age parameters for enrollment, with a minimum of 18 years old and maximum of 65 years old."
Answered by AI
What is the current number of volunteers enrolled in this research endeavor?
"Affirmative. According to the clinicaltrials.gov record, this medical experiment is now recruiting participants with a post date of April 1st 2015 and an update on August 2nd 2022. The study requires 40 test subjects distributed among two sites."
Answered by AI
Has the Federal Drug Administration sanctioned Hyperbaric Oxygen as a legitimate medical treatment?
"As this is a Phase 1 trial, there are only limited data to support both safety and efficacy; therefore, Hyperbaric Oxygen received a score of 1."
Answered by AI
Other Trials to Consider
Popular Categories
Share this study with friends
Copy Link
Messenger