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Genetic Counseling for Cancer Screening (BRIDGE Trial)

N/A
Waitlist Available
Led By Kimberly Kaphingst, PhD
Research Sponsored by University of Utah
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
First degree relative or second degree relative diagnosed with the following <50 years of age: Breast Cancer, Colorectal Cancer, Endometrial Cancer.
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8 weeks and 13 months from pre-test counseling
Awards & highlights

BRIDGE Trial Summary

This trial is testing two ways of delivering genetic testing and cancer screening recommendations to see which is more effective, especially for racial minorities and rural patients.

Who is the study for?
This trial is for individuals of Ashkenazi Jewish descent with a family history of certain cancers, including breast and ovarian cancer. It's open to those who speak English or Spanish and have relatives diagnosed with specific cancers at various ages. People already diagnosed with cancer (except non-melanoma skin cancer) or who've had genetic counseling or testing are excluded.Check my eligibility
What is being tested?
The study aims to compare two ways of delivering genetic services: a patient-directed model versus an enhanced standard care model. It will look at how these models affect the rate of genetic testing uptake, adherence to cancer prevention/screening guidelines, and if there's any difference based on race/ethnicity or living in rural areas.See study design
What are the potential side effects?
Since this trial involves genetic testing and not drug interventions, typical medication side effects are not applicable. However, participants may experience emotional or psychological impacts from learning about their genetic risks for cancer.

BRIDGE Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
A close family member had breast, colorectal, or endometrial cancer before 50.

BRIDGE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 weeks and 13 months from pre-test counseling
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks and 13 months from pre-test counseling for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Completion of genetic testing from electronic health record
Secondary outcome measures
Adherence to management recommendations from genetic counselor: questionnaire
Completion of genetic counseling from electronic health record

BRIDGE Trial Design

2Treatment groups
Active Control
Group I: Patient Directed Standard of CareActive Control1 Intervention
Patients receive pre-test genetic counseling and, if relevant, post-test counseling for a negative result from an automated genetics education assistant.
Group II: Enhanced Standard of CareActive Control1 Intervention
Patients receive standard counseling from a genetic counselor.

Find a Location

Who is running the clinical trial?

University of UtahLead Sponsor
1,095 Previous Clinical Trials
1,773,605 Total Patients Enrolled
New York UniversityOTHER
226 Previous Clinical Trials
312,275 Total Patients Enrolled
Kimberly Kaphingst, PhDPrincipal InvestigatorUniversity of Utah

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there an upper age limitation for participants in this research study?

"Patients aged between 25 and 60 are the only individuals eligible for this specific clinical trial, whereas there are 63 trials catered to those below 18 years old and 435 studies tailored towards seniors over 65."

Answered by AI

Is this program still recruiting participants?

"This investigation, which was submitted to clinicaltrials.gov on February 19th 2020 and last updated October 31st 2022, is no longer enrolling patients. Fortunately, there are currently 491 other studies actively seeking participants for their trials."

Answered by AI

Do I meet the criteria for participation in this clinical experiment?

"This clinical trial is actively recruiting 1980 individuals aged between 25 and 60 suffering from malignancies. To be eligible for inclusion, the patient must have a first or second degree relative with one of the following conditions regardless of their age: Ovarian cancer, Pancreas cancer - OR- A first or second degree relative afflicted with Breast cancer, Colorectal cancer, Endometrial cancer under 50 years old -OR- Ashkenazi Jewish ancestry plus a familial history of at least one out of Breast Cancer, Ovarian Cancer, PancreasCancer or Prostate Cncer."

Answered by AI
Recent research and studies
BMC Health Services ResearchJournal
Comparing Models of Delivery for Cancer Genetics Services Among Patients Receiving Primary Care Who Meet Criteria for Genetic Evaluation in Two Healthcare Systems: BRIDGE Randomized Controlled Trial
Kaphingst, Kimberly A., Wendy Kohlmann, Rachelle Lorenz Chambers, Melody S. Goodman, Richard Bradshaw, Priscilla A. Chan, Daniel Chavez-Yenter, et al.. 2021. “Comparing Models of Delivery for Cancer Genetics Services Among Patients Receiving Primary Care Who Meet Criteria for Genetic Evaluation in Two Healthcare Systems: BRIDGE Randomized Controlled Trial”. BMC Health Services Research. Springer Science and Business Media LLC. doi:10.1186/s12913-021-06489-y.
clinicaltrials.govStudy
Broadening the Reach, Impact, and Delivery of Genetic Services
Kimberly Kaphingst 2020. "Broadening the Reach, Impact, and Delivery of Genetic Services". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03985852.
~383 spots leftby Apr 2025
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