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Biguanide

Metformin for Aging

Phase 1
Waitlist Available
Led By Grace Lee, PhD
Research Sponsored by The University of Texas Health Science Center at San Antonio
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 4 weeks and 8 weeks
Awards & highlights

Study Summary

This trial will test whether the diabetes drug metformin can improve the effectiveness of the pneumococcal vaccine in adults aged 65 and over.

Eligible Conditions
  • Aging
  • Vaccine Response Impaired

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 4 weeks and 8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 4 weeks and 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in antibody responses to PCV13
Secondary outcome measures
Measure of immunophenotypes

Side effects data

From 2015 Phase 4 trial • 156 Patients • NCT02002221
13%
Nasopharyngitis
10%
Hyperhidrosis
9%
Hunger
9%
Tremor
8%
Asthenia
6%
Hypoglycaemia
1%
Squamous cell carcinoma of the tongue
1%
Femoral neck fracture
100%
80%
60%
40%
20%
0%
Study treatment Arm
Vildagliptin (LAF237)
Placebo

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: MetforminExperimental Treatment1 Intervention
Dosage is increased over the first 3 weeks up to three 500 mg tablets a day at 3 weeks, then continued on 3 tablets daily for a further 9 weeks.
Group II: PlaceboPlacebo Group1 Intervention
Placebo tablet dosage is increased over the first 3 weeks up to three tablets a day at 3 weeks, then continued on 3 tablets daily for a further 9 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Metformin
2006
Completed Phase 4
~2430

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

The University of Texas Health Science Center at San AntonioLead Sponsor
453 Previous Clinical Trials
91,412 Total Patients Enrolled
10 Trials studying Aging
1,275 Patients Enrolled for Aging
Grace Lee, PhDPrincipal InvestigatorUT Health San Antonio

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies left in this trial for participants?

"This trial, according to clinicaltrials.gov, is not presently seeking participants as it was last posted on February 7th 2022 and first listed on January 14th 2019. Though this particular study has reached full recruitment status, there are 417 other studies actively searching for participants at present."

Answered by AI

What perilous side effects may arise from Metformin use?

"Metformin has limited clinical evidence in terms of both efficacy and safety, resulting in a score of 1."

Answered by AI

Are there any documented precedents of Metformin being used in medical experiments?

"At present, a total of 170 clinical studies analyzing Metformin are currently in progress; 43 of these trials are at their final phase. Most experiments pertaining to this druge are conducted in Rockville, Maryland; yet 1903 sites worldwide have been conducting research on Metformin as well."

Answered by AI

Is there eligibility criteria for participating in the research trial?

"The trial is accepting up to 18 participants aged 63-90. To qualify, potential enrollees must fall within this age bracket."

Answered by AI

In what medical circumstances is Metformin regularly prescribed?

"Metformin is traditionally used to manage type 2 diabetes but can also be prescribed for diabetic ketoacidosis, polycystic ovary syndrome and other conditions."

Answered by AI

Is the age restriction for this study limited to those under 20?

"According to the study's eligibility requirements, participants must be between 63 and 90 years old. Additionally, there are 22 trials for minors under 18 and 373 studies designed specifically for seniors above 65."

Answered by AI

How many participants are involved in this research endeavor?

"At this point in time, enrollment for the initial trial has been closed. This clinical experiment was introduced on January 14th 2019 and most recently changed February 7th 2022. Alternately, 247 medical studies concerning aging are currently open to participants and 170 investigations related to Metformin require test subjects."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Impact of Metformin on Immunity
2019. "Impact of Metformin on Immunity". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03713801.
~3 spots leftby Jul 2025
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