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Biotin-Labeled Red Blood Cells (RBCs) for Anemia (b-RBCs Trial)

Phase 1
Waitlist Available
Led By John D Roback, MD, PhD
Research Sponsored by Emory University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
in good health
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 12 months
Awards & highlights

b-RBCs Trial Summary

This trial will study how long donated and stored red blood cells survive in a person's circulation.

b-RBCs Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

b-RBCs Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Length of Time Differentially Labeled Biotin-labeled RBCs Can be Distinguished From One Another
Number of Participants That Had bRBC Detectable at 70 Days Post-intervention
Secondary outcome measures
Number of Participants Experiencing Adverse Events

b-RBCs Trial Design

1Treatment groups
Experimental Treatment
Group I: Biotin-Labeled Red Blood Cell (RBC) InfusionExperimental Treatment1 Intervention
Blood will be drawn from participants and labeled with biotin before being re-infused back to the participant. Blood samples will be obtained weekly over 10 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Biotin-Labeled Red Blood Cells (RBCs)
2017
Completed Phase 1
~10

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Emory UniversityLead Sponsor
1,636 Previous Clinical Trials
2,560,568 Total Patients Enrolled
10 Trials studying Anemia
17,535 Patients Enrolled for Anemia
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,834 Previous Clinical Trials
47,310,630 Total Patients Enrolled
101 Trials studying Anemia
18,289 Patients Enrolled for Anemia
John D Roback, MD, PhD4.836 ReviewsPrincipal Investigator - Emory University
Memorial Hospital
Medical School - Emory University
Naval Hospital, Jacksonville, Residency in Family Medicine
5Patient Review
I'm so glad I chose this doctor!

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there precedent for the use of Biotin-Labeled Red Blood Cells (RBCs) in medical research?

"Currently, there are 5 trials related to Biotin-Labeled Red Blood Cells (RBCs) in progress, one of which is at the advanced Phase 3 stage. These research projects can be found across seven different sites with many based in Bethesda, Maryland."

Answered by AI

Are there any openings left for enrolment in this experiment?

"This clinical trial, which was initially publicized on November 1st 2017, is now enrolling participants. Updated information regarding the study was last posted to clinicaltrials.gov on January 26th 2022."

Answered by AI

Are individuals aged 25 or above eligible for enrollment in this experiment?

"According to the study's eligibility requirements, potential participants must be aged between 18-65."

Answered by AI

Is there any hazard associated with Biotin-Labeled Red Blood Cells (RBCs) for human consumption?

"Our group at Power determined that Biotin-Labeled Red Blood Cells (RBCs) is a low risk intervention, with score of 1. This assessment was made due to the fact it's currently within Phase 1 trials and has limited data supporting its safety or efficacy."

Answered by AI

Am I eligible to contribute to this research endeavor?

"To be considered for this medical trial, individuals must have anemia and fall within the age range of 18 to 65. A total of 8 participants are needed."

Answered by AI

How many participants will be included in the current clinical trial?

"Affirmative. Clinicaltrials.gov has reports that this trial, which was published on 11th January 2017, is currently accepting applications. A total of 8 participants are needed for the study and only one research centre will be involved in its execution."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Transfusion of Biotinylated Red Blood Cells
John D Roback 2017. "Transfusion of Biotinylated Red Blood Cells". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02757898.
~1 spots leftby Apr 2025
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