This trial is evaluating whether oral carbohydrate challenge will improve 1 primary outcome in patients with Fasting. Measurement will happen over the course of 5 hours.
This trial requires 50 total participants across 2 different treatment groups
This trial involves 2 different treatments. Oral Carbohydrate Challenge is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
Fasting is primarily a social behaviour in humans based on a complex interplay of physiological, psychological and socio-cultural factors. Eating has evolved to be a social interaction that can be modulated to meet a range of needs, whilst maintaining the nutritional status necessary to prevent or treat disease. In most cultures, both men and women regularly go without food at certain times in their lives - these 'fasts'. They often do so in an effort to promote fasting. The fasting that humans undertake is not a single process but an assortment of different methods that are often related to local cultural and health practices. These include 'dietarian fasting','monitorial fasting' and 'total fast'.
Fasting is a common human behavior. A person may be on a diet, may want to prepare for an annual medical exam, may be tired in a medical office, or may simply need to get ahead of the game. This paper describes the various ways in which a person can become and stay in a state of fasting for a period of time.
Fasting seems to be associated with a normalization of insulin resistance. Fasting could possibly play a role in the control of type 2 diabetes. Results from a recent paper of the present study imply that fasting may have a role in the control of type 2 diabetes, but prospective studies are still needed.
Fasting as a treatment for eating disorders or obesity is commonly practiced in the outpatient setting, yet the underlying mechanisms and benefits are unclear. The data reveal that fasting as a treatment for anorexia nervosa or cachexia reduces BMI-SDS, body fat %, waist circumference, and increases levels of FMD with or without weight gain. In a recent study, findings support the notion that fasting can be an effective treatment of eating disorders and obesity with a short- and long-term risk-benefit profile.
About 1 in 5 men over the age of 30 have an overnight fasted every day, and nearly 11% skip one or more fasting days in a year. Although more common in the United States than in Germany, Portugal, and United Kingdom, this practice is less common in other developed countries and more common in developing countries.
Fasting is a dietary treatment option. Fasting results in substantial weight loss (6 to 11 kg or 13.3 to 30 lb) along with a reduction in triglycerides and insulin resistance in many patients with metabolic syndrome or lipodystrophy. Most patients experience weight regain within 3 months of ending the fasting cycle. Fasting can also be successfully used to achieve greater than 10% weight loss, but it is challenging to achieve greater than 15%. Fasting is safe for patients with end-stage hepatitis or cirrhosis. Patients should not embark on a permanent calorie restricted diet if they do not have cirrhosis.
Carbohydrate challenge causes an increase in body temperature and a decrease in heart rate. Gastric bloating, nausea, vomiting, and abdominal pain are transiently experienced. The incidence of moderate to severe abdominal pain is higher after carbohydrate loading with a low-carbohydrate, high-fiber diet.
Carbohydrates elicit a greater appetite than any other type of ingested nourishment in normal and diabetic humans. When consumed in an adequate dose and timing, carbohydrate ingestion can reduce food intake and appetite, which may aid in the treatment of starvation-induced anorexia.
In this pilot study, people diagnosed with AN who reported fasting as their primary means of weight loss demonstrated elevated insulin and elevated glucose levels and were significantly more likely to be obese; therefore, patients should be counselled on this relationship and the risk factors for fasting.
Families with long histories of fasting seem to have a greater degree of inheritance. Further research into the genetic mechanism underlying this association should aid in understanding the effects of prolonged fasting in health and disease.
The challenge of OCCs (Oral Carbohydrate Challenge) is a simple, non-invasive, and economical method. It allows subjects to become adaptable and thus helps them maintain a carbohydrate balance. This method can also promote recovery of patients who have experienced a ketosis-like condition; it may also aid in treating type 2 diabetes mellitus and other neurological conditions.
Fasting is a common practice among many populations, including adolescents, women and health professionals; however, the health benefits of fasting are controversial. This review highlights the latest research findings on fasting, and identifies the evidence for potential health benefits of fasting and the risk of harm.