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Corticosteroid

Aerobic Exercise for Aging (ACE Trial)

Phase 1

Waitlist Available

Led By Keith M. McGregor, PhD MS BA

Research Sponsored by VA Office of Research and Development

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Living persons aged 50-85

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up pre/post 12 week intervention

Awards & highlights

ACE Trial Summary

This trial will study how changes in GABAergic function due to aging affect motor performance, and how aerobic exercise may improve this function and help with motor learning.

Who is the study for?

This trial is for individuals aged 50-85 who are generally not engaged in vigorous physical labor or exercise weekly. It's not suitable for those with unmanaged diabetes or conditions that make MRI scans unsafe.Check my eligibility

What is being tested?

The study examines how aerobic exercise versus stretching and balance training affects brain function related to movement control as people age, specifically looking at the role of a neurotransmitter called GABA.See study design

What are the potential side effects?

While specific side effects are not detailed, typical risks may include muscle soreness, fatigue, and potential strain from physical activities like aerobic exercises.

ACE Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 50 and 85 years old.

ACE Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ pre/post 12 week intervention

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~pre/post 12 week intervention

This trial's timeline: 3 weeks for screening, Varies for treatment, and pre/post 12 week intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Magnetic Resonance Spectroscopy

Secondary outcome measures

Transcranial Magnetic Stimulation

ACE Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Aerobic ExerciseExperimental Treatment1 Intervention

Participants will engage in an aerobic exercise program meeting thrice weekly for a period of 12 weeks.

Group II: Stretching and Balance TrainingActive Control1 Intervention

Participants will engage in a balance and stretching comparator condition meeting thrice weekly for 12 weeks.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Aerobic Exercise

2013

Completed Early Phase 1

~1310

0 / 1Eligibility criteria met

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor

1,609 Previous Clinical Trials

3,306,573 Total Patients Enrolled

23 Trials studying Aging

2,789 Patients Enrolled for Aging

Keith M. McGregor, PhD MS BAPrincipal InvestigatorAtlanta VA Medical and Rehab Center, Decatur, GA

1 Previous Clinical Trials

33 Total Patients Enrolled

1 Trials studying Aging

33 Patients Enrolled for Aging

Joe R. Nocera, PhDPrincipal InvestigatorAtlanta VA Medical and Rehab Center, Decatur, GA

4 Previous Clinical Trials

338 Total Patients Enrolled

1 Trials studying Aging

40 Patients Enrolled for Aging

Media Library

Aerobic Exercise (Corticosteroid) Clinical Trial Eligibility Overview. Trial Name: NCT03750903 — Phase 1

Aging Research Study Groups: Aerobic Exercise, Stretching and Balance Training

Aging Clinical Trial 2023: Aerobic Exercise Highlights & Side Effects. Trial Name: NCT03750903 — Phase 1

Aerobic Exercise (Corticosteroid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03750903 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are seniors in this age demographic being enlisted for participation?

"This clinical trial requires participants to meet a certain age criteria with the youngest being 50 years old and the eldest at 85."

Answered by AI

Are there vacancies available for participation in this investigation?

"Affirmative, the information on clinicaltrials.gov implies that this trial is looking for enrollees. Initially posted on March 4th 2019 and updated June 30th 2022, it seeks to recruit 48 patients from one medical facility."

Answered by AI

How many individuals are involved in this research endeavor?

"Indeed, according to information found on clinicaltrials.gov, this trial is presently looking for participants. It was first unveiled on March 4th 2019 and its parameters were last updated June 30th 2022. Up to 48 patients will be recruited from one centre."

Answered by AI

What potential adverse effects are associated with aerobic exercise?

"Due to the limited data available as a result of this being a Phase 1 trial, Aerobic Exercise is estimated to be safe with a score of 1."

Answered by AI

Is the opportunity available to join this experiment open at present?

"This medical trial is seeking 48 individuals aged 50-85. To be included in the study, patients must meet all eligibility requirements which state that participants need to currently reside and have a chronological age between 50-85 years old."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Aging and Cortical Excitability

2019. "Aging and Cortical Excitability". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03750903.

All > Aging