Study Summary
This trial is testing a new drug to see if it can help people with obesity lose weight by reducing hunger, cravings, and stress.
Treatment Effectiveness
Effectiveness Progress
Study Objectives
3 Primary · 3 Secondary · Reporting Duration: week 0, 4, 8, 12
Week 12
Change in Craving
Change in Food Intake
Change in Hunger
Week 0
Change in food intake - real-life
Change in stress
weekly for 12 weeks
Change in weight
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
GLP-1a
1 of 2
Placebo
1 of 2
Experimental Treatment
Non-Treatment Group
96 Total Participants · 2 Treatment Groups
Primary Treatment: GLP-1 analogue - semaglutide · Has Placebo Group · Phase 1
GLP-1a
Drug
Experimental Group · 1 Intervention: GLP-1 analogue - semaglutide · Intervention Types: DrugPlacebo
Other
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: OtherTrial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: week 0, 4, 8, 12
Who is running the clinical trial?
Yale UniversityLead Sponsor
1,679 Previous Clinical Trials
21,087,943 Total Patients Enrolled
58 Trials studying Obesity
248,096 Patients Enrolled for Obesity
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,148 Previous Clinical Trials
4,074,683 Total Patients Enrolled
403 Trials studying Obesity
492,889 Patients Enrolled for Obesity
Ania Jastreboff, MD, PhDPrincipal InvestigatorInternal Medicine (Endocrinology) and Pediatrics (Pediatric Endocrinology);
Rajita Sinha, PhDPrincipal InvestigatorPsychiatry; Director Yale Stress Center
13 Previous Clinical Trials
1,943 Total Patients Enrolled
3 Trials studying Obesity
314 Patients Enrolled for Obesity
Eligibility Criteria
Age 18 - 55 · All Participants · 5 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:She can speak English and read English well enough to complete study evaluations.
Can provide written or verbal consent that is informed.
This text is saying that there is no history of people with an HgbA1c level of less than 6.5%.
Who else is applying?
What state do they live in?
| New York | 66.7% |
| California | 33.3% |
How old are they?
| 18 - 65 | 100.0% |
What site did they apply to?
| The Yale Stress Center: Yale University | 100.0% |
What portion of applicants met pre-screening criteria?
| Did not meet criteria | 66.7% |
| Met criteria | 33.3% |
Why did patients apply to this trial?
- "I’ve tried other over the counter weight loss aids but nothing worked. I’m interested in trying new drugs or technologies that might prove to help me lose my belly fat"
How many prior treatments have patients received?
| 1 | 100.0% |
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Conditions
Cancer Related
Treatments