EngageRx for High Blood Pressure

Overseen By Mark Pletcher, MD MPH

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of California, San Francisco

Disqualifiers: Unable to use BP monitor, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 3 months

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new tool called EngageRx_SMBP, a self-monitoring blood pressure tool, to help manage high blood pressure. The goal is to assess its ease of use for both patients and doctors and its potential to improve blood pressure control. It targets adults with high blood pressure during doctor visits at UCSF. Participants must speak English or Spanish and feel comfortable using a blood pressure monitor at home. As an unphased trial, this study allows participants to contribute to innovative research that could enhance blood pressure management for many.

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It seems focused on monitoring blood pressure, so you might be able to continue your current treatment, but it's best to confirm with the trial organizers.

What prior data suggests that EngageRx_SMBP is safe for high blood pressure management?

Research shows that EngageRx_SMBP focuses on the ease and satisfaction of using a new system for checking blood pressure at home. Detailed safety information for EngageRx_SMBP is not yet available, but it is important to note that this trial does not involve testing a new drug or any surgical procedure. Instead, it evaluates a tool for monitoring blood pressure.

As an early study, it primarily examines the tool's user-friendliness and satisfaction. Generally, non-invasive tools like this are well-tolerated, as they do not involve medication or surgery. In early trials focusing on usability, the tool being tested usually poses no significant risk. ^{1 2 3 4 5}

Why are researchers excited about this trial?

EngageRx_SMBP is unique because it integrates self-monitoring of blood pressure (SMBP) with a digital health platform, which is a step beyond traditional blood pressure management methods like medication and lifestyle changes. Unlike standard treatments that rely solely on regular check-ups and antihypertensive drugs, EngageRx_SMBP empowers patients to track their own blood pressure in real-time, providing immediate feedback and personalized insights. Researchers are excited about this treatment because it has the potential to improve patient engagement and adherence, leading to better long-term control of high blood pressure.

What evidence suggests that EngageRx_SMBP is effective for high blood pressure?

Research shows that checking blood pressure at home, known as self-measured blood pressure monitoring (SMBP), can improve high blood pressure management. Studies have found that SMBP allows patients to track their blood pressure more accurately, leading to significant reductions in their levels. One study discovered that combining home blood pressure checks with health coaching greatly improved blood pressure control. Monitoring blood pressure at home can also help identify risks early, as even a small rise can increase the chance of heart issues. Overall, these findings suggest that EngageRx_SMBP, the treatment under study in this trial, could effectively help manage high blood pressure by providing patients a better way to monitor and respond to their blood pressure levels. ^{6 7 8 9 10}

Who Is on the Research Team?

Mark Pletcher, MD MPH

Principal Investigator

University of California, San Francisco

Are You a Good Fit for This Trial?

This clinical trial is for patients with high blood pressure being treated at UCSF General Internal Medicine practice. It aims to test the usability and satisfaction of a new self-measurement blood pressure system, EngageRx_SMBP, among 70 participants.

Inclusion Criteria

Lowest SBP > 140 or lowest DBP > 90 during the visit at one of the Mt. Zion General Internal Medicine practices

I am over 18 and have high blood pressure that isn't controlled.

Exclusion Criteria

Patient is unlikely to be able to use a home BP monitor

Cannot understand the verbal consent

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants use the EngageRx_SMBP system for integrated self-measurement of blood pressure

3 months

Follow-up

Participants are monitored for usability, satisfaction, and BP-related process metrics after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• EngageRx_SMBP

Trial Overview The study is testing EngageRx_SMBP, a tool for patients to measure their own blood pressure. The focus is on how well it works and if people like using it. Researchers will also look at how quickly doctors adjust medications or achieve BP control when using this system.

How Is the Trial Designed?

Group I: EngageRx_SMBP Experimental Treatment 1 Intervention

Integrated SMBP monitoring using EngageRx\_SMBP.

Who Is Running the Clinical Trial?

University of California, San Francisco

Lead Sponsor

Trials

2,636

Recruited

19,080,000+

National Institutes of Health (NIH)

Collaborator

Trials

2,896

Recruited

8,053,000+

New York University

Collaborator

Trials

249

Recruited

229,000+

Citations

1. ncbi.nlm.nih.gov ncbi.nlm.nih.gov/books/NBK84600/

Executive Summary - Self-Measured Blood Pressure Monitoring The primary objective of this review is to evaluate whether the use of SMBP monitoring influences outcomes in adults and children with hypertension.

2. pcori.org pcori.org/research-results/2024/comparing-effectiveness-two-strategies-improve-high-blood-pressure-older-adults-living-multiple-chronic-diseases

Comparing the Effectiveness of Two Strategies To Improve ... This study compares the effectiveness of two health system strategies to improve high blood pressure in older adults living with multiple ...

3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC1490290/

Hypertension Outcomes Through Blood Pressure ... In a study on the prognostic value of home BP readings, each 10 mmHg increase in SBP provided 17.2% increased risk of cardiovascular events. Similarly, meta- ...

4. eshonline.org eshonline.org/annual-meeting-posts/accomplish-early-lessons-from-the-blood-pressure-and-outcomes-data/

Early Lessons from the Blood Pressure and Outcomes Data Overall, initial fixed-dose combinations produced remarkable BP control rates including difficult-to-treat patient subgroups such as those with diabetes or ...

5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC5788021/

Comparative Effectiveness of Implementation Strategies for ... Our findings also showed that health coaching and home BP monitoring alone resulted in significant BP reduction among hypertensive patients. Health coaching is ...

6. withpower.com withpower.com/trial/engagerx-for-high-blood-pressure-56e01

EngageRx for High Blood Pressure · Info for Participants It aims to test the usability and satisfaction of a new self-measurement blood pressure system, EngageRx_SMBP, among 70 participants. Inclusion Criteria. Lowest ...

7. file.glpbio.cn file.glpbio.cn/quotepdf/sds.php?token=3RCz7_0O3A5TMfmD7Aru5ZJ48uDahL7STdDG8hk2gcOc3VntS-DbFQY6e7uwGtChZAcUGT4ItqG25EcOkr3w2-tVbEa2_1Kys0KTZW8VcPC47O_kkRMz6DYLSHCmRRt1q-Wdkwcc8Tw4O

Safety Data Sheet 1.1 Product identifier. Product name: Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt). Catalog No.: GC46856.

8. who.int who.int/news-room/fact-sheets/detail/hypertension

Hypertension Hypertension (high blood pressure) is when the pressure in your blood vessels is too high (140/90 mmHg or higher). It is common but can be serious if not ...

9. file.medchemexpress.eu file.medchemexpress.eu/batch_PDF/HY-P3910/Val4-Angiotensin-III-SDS-MedChemExpress.pdf

[Val4] Angiotensin III-SDS-MedChemExpress No data available. Flammability (solid, gas). No data available. Upper/lower flammability or explosive limits. No data available. Vapor pressure.

10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC8902065/

Associations Between Household Pesticide Exposure ... This study suggests that household pesticide exposure is associated with an elevated risk of hypertension. We also report that smoking may accentuate the ...