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Increased venous pressure for Vascular Disease

Phase < 1
Waitlist Available
Led By Pekka Talke, MD
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 minutes
Awards & highlights

Study Summary

This study is evaluating whether there are differences in the frequency and amplitude of myogenic oscillations in people with and without anesthesia.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
myogenic oscillations

Trial Design

6Treatment groups
Experimental Treatment
Group I: tetanic stimulusExperimental Treatment1 Intervention
A 5 second 70 mA tetanic stimulus will be used to increase peripheral vascular tone
Group II: PhenylephrineExperimental Treatment1 Intervention
Phenylephrine (100 ug/ml) infusion will be used to increase blood pressure by 20 mmHg
Group III: Increased venous pressureExperimental Treatment1 Intervention
A 5 minute inflation of a noninvasive blood pressure cuff to 30 mmHg to increase venous pressure in the arm.
Group IV: DexmedetomidineExperimental Treatment1 Intervention
Dexmedetomidine infusion will be used to increase blood pressure by 20 mmHg
Group V: ClevidipineExperimental Treatment1 Intervention
Clevidipine infusion will be used to increase blood pressure by 20 mmHg
Group VI: Calcium ChlorideExperimental Treatment1 Intervention
Calcium Chloride will be administered to increase blood pressure and to increase blood calcium concentration
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Phenylephrine
2014
Completed Phase 4
~2050
Dexmedetomidine
2015
Completed Phase 4
~1980
Clevidipine
2012
Completed Phase 4
~230
Calcium Chloride
2019
Completed Phase 2
~480

Find a Location

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor
2,505 Previous Clinical Trials
15,237,515 Total Patients Enrolled
Pekka Talke, MDPrincipal InvestigatorUniversity of California, San Francisco
3 Previous Clinical Trials
38 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Effect of Changing Physiological Conditions on Myogenic Oscillations: Pilot Study
2018. "Effect of Changing Physiological Conditions on Myogenic Oscillations: Pilot Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03719001.
~6 spots leftby Apr 2025
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