← Back to Search

PET Imaging for Substance Use Disorders

Phase < 1
Recruiting
Led By Kelly Cosgrove, PhD
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Not treatment seeking or using treatment medications
Men and women, aged 18-55 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 120 minute pet scan acquisition. drug of dependence will be given at -35 mins
Awards & highlights

Study Summary

This trialwill use PET technology to study the effects of drugs of abuse (marijuana, cigs, cocaine) on dopamine and opioid systems.

Who is the study for?
This trial is for men and women aged 18-55 who smoke tobacco regularly or use marijuana but are not seeking treatment. Participants must be able to consent in English, have a certain level of nicotine dependence, and not use other illicit drugs or significant medications. Pregnant/nursing women, those with major medical/psychiatric conditions, or MRI-incompatible implants cannot join.Check my eligibility
What is being tested?
The study uses PET scans to examine the effects of substances like marijuana, cigarettes, and cocaine on dopamine and opioid neurotransmitter systems in the brain. It aims to advance understanding of drug addiction's neurochemistry using cutting-edge imaging technology.See study design
What are the potential side effects?
While the document does not specify side effects from PET scanning itself, common ones can include discomfort at injection site for tracer substance used in PET scan; allergic reactions are rare but possible.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am not currently seeking or using any treatment medications.
Select...
I am between 18 and 55 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~90 minute pet scan acquisition. drug of dependence will be given at -35 mins
This trial's timeline: 3 weeks for screening, Varies for treatment, and 90 minute pet scan acquisition. drug of dependence will be given at -35 mins for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in beta endorphin levels at baseline and after drug of dependence administration as confirmed by PET images.
Change in dopamine levels at baseline and after drug of dependence administration as confirmed by PET images.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Drug of dependenceExperimental Treatment1 Intervention
There is only one arm to the study. All subjects will receive their drug of dependence in this study. Nicotine dependent subjects will receive tobacco cigarettes, cannabis dependent subjects will receive cannabis cigarettes, and cocaine dependent subjects will receive IV cocaine.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
cannabis
2013
Completed Phase 1
~440

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,851 Previous Clinical Trials
2,738,123 Total Patients Enrolled
14 Trials studying Cannabis
734 Patients Enrolled for Cannabis
National Institute on Drug Abuse (NIDA)NIH
2,468 Previous Clinical Trials
2,619,259 Total Patients Enrolled
20 Trials studying Cannabis
1,446 Patients Enrolled for Cannabis
Kelly Cosgrove, PhDPrincipal Investigator - Yale University
Yale University
7 Previous Clinical Trials
346 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this an innovative clinical trial?

"Since 2015, cannabis has been subject to clinical trials. Jazz Pharmaceuticals had the honour of sponsoring the first one in that same year; it was a Phase 1 study with 200 participants. Following this initial trial, cannabis received its Phase 2 & 3 drug approval and today is being studied across 33 cities and 5 countries worldwide via 32 active studies."

Answered by AI

Are there any open slots remaining in this clinical investigation?

"Affirmative, clinicaltrials.gov has evidence that this research project is actively searching for qualified patients. The study was first published on November 29th 2017 and its latest iteration occurred December 6th 2022. All in all, 90 participants need to be enrolled from 3 distinct locations."

Answered by AI

How many participants have enrolled in the experiment thus far?

"Affirmative. Clinicaltrials.gov reveals that the trial is presently looking for 90 participants to be recruited from three sites, with its initial posting on November 29th 2017 and most recent update being December 6th 2022."

Answered by AI

Is participation in this medical study open to all qualified applicants?

"The study is seeking 90 people who have been smoking tobacco for a minimum of 12 months and consume at least 7 cigarettes daily. Eligible candidates must be aged 18-55, not using any form of therapeutic medication, abstaining from marijuana or other illicit drugs and non-treatment seekers."

Answered by AI

Is the age bracket for this trial inclusive of those younger than 45 years?

"As stated in the prerequisites for participation, no one under 18 or over 55 can join this clinical trial."

Answered by AI

Are there any precedents of research involving cannabis?

"Presently, there are 32 live cannabis trials taking place with 3 in the later stages of development. Hartford Connecticut is home to most of these studies but 49 centres across the USA offer clinical cannabis research opportunities."

Answered by AI

Who else is applying?

What state do they live in?
Connecticut
What site did they apply to?
Connecticut Mental Health Center
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

I believe that is that it is imirritate that we find out more about cannabis. And it's wonderful elements. Quality of life is everything, I think we all need to live our best life. And integrate cannabis infor the good..
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Imaging the Neurochemistry of Drug Addiction With PET
Kelly Cosgrove 2017. "Imaging the Neurochemistry of Drug Addiction With PET". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02817698.
All > Opiate Addiction > Addiction
~4 spots leftby Sep 2024
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top