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Tetracycline Antibiotic

Doxycycline for Ocular Rosacea

Phase < 1
Waitlist Available
Led By Mark Mannis, MD
Research Sponsored by University of California, Davis
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1-5 weeks
Awards & highlights

Study Summary

This trial seeks to understand how rosacea affects the body's lipid profile and how antibiotics change the microbiome in those with the condition.

Eligible Conditions
  • Ocular Rosacea
  • Rosacea

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1-5 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1-5 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Lipidome Change in Diversity
Lipidome Change in Quantity
Microbiome Change in Diversity
+1 more

Side effects data

From 2021 Phase 4 trial • 26 Patients • NCT04167085
4%
Sinus infection
4%
Metastatic lung cancer dx
4%
Blurred vision
4%
Foot infection
4%
Emesis
4%
Pneumonia
100%
80%
60%
40%
20%
0%
Study treatment Arm
Doxycycline
Placebo

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Ocular Rosacea SubjectsExperimental Treatment1 Intervention
Ocular rosacea subjects will receive mandatory Doxycycline intervention and will have samples collected at two visits, before starting intervention and at the completion of the intervention.
Group II: Cutaneous Rosacea SubjectsExperimental Treatment1 Intervention
Doxycycline intervention is optional for cutaneous rosacea subjects. If they do not participate, samples will only be collected at one visit after Dove soap washout. If they do decide to participate, samples will also be collected after completion of the Doxycycline intervention.
Group III: Healthy SubjectsActive Control1 Intervention
Healthy subjects will receive no intervention and will have samples collected only at one visit after Dove soap washout.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Doxycycline
2008
Completed Phase 4
~2430

Find a Location

Who is running the clinical trial?

University of California, DavisLead Sponsor
911 Previous Clinical Trials
4,709,489 Total Patients Enrolled
Mark Mannis, MDPrincipal InvestigatorUC Davis, Department of Ophthalmology
Raja Sivamani, MD, MSPrincipal InvestigatorUC Davis, Department of Dermatology

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Lipidome and Microbiome Profile of the Eye in Rosacea
2017. "Lipidome and Microbiome Profile of the Eye in Rosacea". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03655197.
~4 spots leftby Apr 2025
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