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Contrave for Stimulant Abuse
Study Summary
This trial is designed to study the effects of Bupropion and Contrave on Stimulant users in inpatient treatment for stimulant-use disorder with and without ADHD. The study will last for 8 weeks and will track the progress of the participants through four assessments.
- Stimulant Abuse
- Relapsing
- Cognitive Functioning
- Attention Deficit Hyperactivity Disorder (ADHD)
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Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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- You have had a bad reaction to Bupropion or Naltrexone in the past.You have had a severe brain injury where you lost consciousness for more than 30 minutes.You haven't used any illegal drugs (except for nicotine in cigarettes) for 2-8 weeks.a. You are currently taking medications like bupropion, naltrexone, opiates or opiate-substitutes, or stimulants.
b. You are currently taking medications that directly affect certain brain chemicals like dopamine or serotonin.
c. You are currently taking any neuroleptic medications.
d. You are currently taking systemic corticosteroids or xanthines like theophylline.
e. You are currently taking sympathomimetic medications.
f. You are currently taking antiretroviral medications like nelfinavir, ritonavir, and efavirenz.
g. You are currently taking linezolid or IV methylene blue.
h. You are currently taking warfarin.You have taken MAO-I medication within the two weeks before the study starts.You have a condition or injury that affects both of your eyes and makes it hard for you to see or complete computer tasks that test your thinking abilities. Examples include glaucoma (a condition that damages your optic nerve) and colorblindness (a condition that makes it difficult to see certain colors).You are currently having thoughts about hurting yourself or have a plan to do so, as determined by a special assessment called the MINI.You have received electroconvulsive therapy in the past 90 days before the screening.You have been diagnosed with asthma or COPD, including having had a recent asthma attack within the past 2 years. You are currently taking theophylline or have a lung function test showing an FEV1 of less than 70%.You have been diagnosed with a stimulant-use disorder according to the DSM 5 guidelines.You have a history of seizures or conditions that make you more prone to having seizures, such as certain brain disorders or substance abuse.
- Group 1: Contrave
- Group 2: Bupropion
- Group 3: Treatment As Usual
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Approved for 10 Other Conditions - This treatment demonstrated efficacy for 10 other conditions.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there currently any enrollment opportunities for individuals in this investigation?
"Clinicaltrials.gov shows that this medical research is not recruiting participants at the moment, despite first being announced on June 11th 2023 and lastly edited on August 31st 2022. Fortunately, there are 1,265 other clinical trials seeking enrolments right now."
How many volunteers are anticipated to register for this experiment?
"This research initiative is not presently accepting new test subjects. It was first posted on June 11th 2023 and most recently updated in August 31st 2022. If you are seeking alternative trials, 1201 studies that involve cognitive functioning are actively recruiting, whereas 64 investigations into Contrave are open for enrollment at this time."
Does this research protocol have an age limitation?
"The eligibility requirements for this clinical trial necessitate that candidates are between 18 and 65 years old. For those under eighteen, there are 267 trials available while 1005 exist to serve seniors over the age of sixty-five."
What therapeutic purpose is Contrave customarily prescribed for?
"Contrave is frequently prescribed for ADHD management. Additionally, it has been known to be beneficial in treating Seasonal Affective Disorder, nicotine addiction and smoking cessation."
What is the principal aim of this research endeavor?
"This 84-day medical trial aims to assess Stimulant use one month post inpatient treatment (urine toxicology). Secondary objectives are examining Inhibitory control - Reversal Learning, Decision Making under Risk and Ambiguity, and Sustained Attention at various intervals throughout the study. The Continuous Performance Task will be used to measure sustained attention, while a reversal learning task is employed for inhibitory control evaluation; risk/ambiguity decision making is gauged through computer program testing."
What demographic is most appropriate for trial participation in this experiment?
"This clinical trial seeks 60 individuals, aged 18-65 years old and with existing cognitive capability. Additionally, they must have abstained from drugs (apart from nicotine) for 2-8 weeks prior to the study; be free of any medical condition that could impede their participation according to a physical assessment by an admitting physician or principal investigator; willingly enter into treatment and maintain it for the duration of the trial; possess normal cardiac conduction as revealed by an electrocardiogram without any notable arrhythmias."
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