Oral Calcium for Postpartum Hemorrhage
Trial Summary
What is the purpose of this trial?
This study investigates the time course of change in calcium in the blood after a pregnant subject takes an oral dose of calcium carbonate (commonly marketed as "Tums"). This information is important for trials investigating whether calcium can reduce postpartum hemorrhage, bleeding after delivery.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are taking digoxin or a calcium channel blocker.
What data supports the effectiveness of the drug oral calcium carbonate for postpartum hemorrhage?
Research shows that oral calcium carbonate can effectively increase calcium levels in the blood, which may help in conditions where calcium plays a role in blood clotting. Additionally, it has been used successfully in other medical conditions to manage calcium levels, suggesting potential benefits in managing postpartum hemorrhage.12345
Is oral calcium carbonate safe for humans?
How does the drug oral calcium carbonate differ from other treatments for postpartum hemorrhage?
Oral calcium carbonate is unique because it is administered orally, which is less invasive than other treatments for postpartum hemorrhage that may require injections or surgical interventions. Additionally, it is commonly used to manage calcium levels in other conditions, suggesting it may help stabilize calcium levels during postpartum hemorrhage.2351112
Research Team
Jessica Ansari, MD, MS
Principal Investigator
Stanford University
Eligibility Criteria
This trial is for pregnant women aged 18-45, admitted for labor or cesarean delivery without cardiac disease, arrhythmia, severe blood pressure issues, renal dysfunction, or on certain medications like calcium channel blockers and digoxin. They should weigh between 55kg and 100kg.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants take a single dose of oral calcium carbonate 3000mg
Follow-up
Participants are monitored for changes in ionized calcium concentration over 4 hours
Treatment Details
Interventions
- Oral Calcium Carbonate
Find a Clinic Near You
Who Is Running the Clinical Trial?
Stanford University
Lead Sponsor