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Radiopharmaceutical

Main for Obesity

Phase < 1
Waitlist Available
Led By Kevin Hall, Ph.D.
Research Sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up assessed at days 2-5
Awards & highlights

Study Summary

This trial is testing if measuring dopamine activity in the brain can help explain why some people struggle with maintaining a healthy weight.

Eligible Conditions
  • Obesity
  • Healthy Subjects

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~assessed at days 2-5
This trial's timeline: 3 weeks for screening, Varies for treatment, and assessed at days 2-5 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Striatal Dopamine D2BP After a Palatable Meal
Correlation Between Change in Striatal Dopamine D2BP After a Palatable Meal and BMI
Correlation Between Striatal D2 Receptor Binding Potential (D2BP) as Measured by [18F]Fallypride and [11C]Raclopride Time-activity Curves
+1 more
Secondary outcome measures
Associations Between Behavioral Performance on Food Go/No Go Computer Task and Striatal D2BP
Associations Between Brain Metabolite GABA Via MRS and Striatal D2BP Via [18F]Fallypride
Associations Between ad Libitum Meal Consumption and Striatal D2 Receptor (D2R)

Trial Design

1Treatment groups
Experimental Treatment
Group I: MainExperimental Treatment2 Interventions
Healthy volunteers, within three BMI strata, under controlled overnight fasting conditions following a period of dietary stabilization
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
[c11] raclopride
2018
Completed Early Phase 1
~70
[18F]fallypride
2018
Completed Early Phase 1
~70

Find a Location

Who is running the clinical trial?

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Lead Sponsor
2,359 Previous Clinical Trials
4,315,434 Total Patients Enrolled
446 Trials studying Obesity
588,877 Patients Enrolled for Obesity
Kevin Hall, Ph.D.Principal InvestigatorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
10 Previous Clinical Trials
509 Total Patients Enrolled
6 Trials studying Obesity
453 Patients Enrolled for Obesity

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the ultimate goals of this clinical investigation?

"This trial is set to run for approximately six months, and its primary aim is to assess the influence of palatable meal consumption on D2BP in participants with a broad BMI range. Using [11C]raclopride as an estimate, secondary objectives include inspecting correlations between GABA levels measured via MRS and striatal binding potentials evaluated using [18F]fallypride. Furthermore, exploratory analyses will evaluate how these metrics are associated with participant's BMI while they complete cognitive tasks related to food intake and self-control. Female volunteers may also need to take urine pregnancy tests prior to participating; any positive results will render"

Answered by AI

Is the research team still recruiting participants for this experiment?

"Unfortunately, according to clinicaltrials.gov records this medical trial is not presently recruiting patients; the posting was first published on September 21st 2018 and last edited on June 30th 2022. However, there remain 1,943 other studies that are actively looking for participants at present."

Answered by AI

How many participants is this clinical trial currently accommodating?

"At the moment, this trial is no longer accepting candidates. Initially posted on September 21st 2018, and last updated on June 30th 2022, there are 1941 obesity-related clinical trials actively seeking patients in addition to two studies for this treatment that require additional enrollees."

Answered by AI

Is this treatment being tested in other scientific experiments?

"Currently, two clinical trials are exploring this treatment's effectiveness and none of them have moved beyond phase 3. While Bethesda is one hub for research on the medication, other study sites exist too."

Answered by AI
~9 spots leftby Apr 2025