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MRI + Liquid Biopsy for Early Cancer Detection

Phase < 1
Recruiting
Led By Dan Raz
Research Sponsored by City of Hope Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Any cancer diagnosis within past 5 years, excluding non-melanoma skin cancer
Have a family history of early-onset cancer (age >40) in at least one first-degree relative
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 6 months after wbm
Awards & highlights

Study Summary

This trial evaluates if MRI and liquid biopsy can detect early cancer in those with a strong family history of it.

Who is the study for?
This trial is for adults with a strong family history of cancer, particularly those who are at least 50 years old or within 10 years of the age their relative was diagnosed with cancer. Participants must have multiple relatives with cancer and be willing to undergo genetic counseling, germline testing, and MRI scans without contrast. They should not have had any type of whole body imaging in the last three years or show signs/symptoms suggesting current cancer.Check my eligibility
What is being tested?
The study is looking into how acceptable it is for patients to use whole body magnetic resonance imaging (MRI) and liquid biopsies as methods for early detection of cancers in individuals at high risk due to family history. It aims to see if these techniques can identify early-stage cancers more effectively than traditional organ-specific screenings.See study design
What are the potential side effects?
There may be minimal side effects from participating in this trial since it involves non-invasive procedures like blood draws and MRI scans. However, some people might experience discomfort from lying still during the MRI or anxiety about being in a confined space.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with cancer other than non-melanoma skin cancer in the last 5 years.
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A close family member had cancer before 40.
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I don't have symptoms like coughing up blood, lumps, bleeding, or unexplained weight loss.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 6 months after wbm
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 6 months after wbm for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Acceptability of germline testing, liquid biopsy and whole body magnetic resonance imaging (WBM)
Secondary outcome measures
Health Related Quality of Life (HRQOL/Germline)
Health Related Quality of Life (HRQOL/LB)
Health Related Quality of Life (HRQOL/WBM)
+7 more
Other outcome measures
Correlation between high-risk liquid biopsy findings and cancer detected on WBM

Trial Design

1Treatment groups
Experimental Treatment
Group I: Whole Body MRI and Liquid BiopsyExperimental Treatment5 Interventions
Patients undergo WBM without contrast and blood sample collection for liquid biopsy
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Biospecimen Collection
2004
Completed Phase 2
~1920

Find a Location

Who is running the clinical trial?

City of Hope Medical CenterLead Sponsor
561 Previous Clinical Trials
1,918,152 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,627 Previous Clinical Trials
40,927,295 Total Patients Enrolled
1 Trials studying Blood Cancers
70 Patients Enrolled for Blood Cancers
Dan RazPrincipal InvestigatorCity of Hope Medical Center
3 Previous Clinical Trials
410 Total Patients Enrolled

Media Library

Whole Body MRI and Liquid Biopsy Clinical Trial Eligibility Overview. Trial Name: NCT05868486 — Phase < 1
Blood Cancers Research Study Groups: Whole Body MRI and Liquid Biopsy
Blood Cancers Clinical Trial 2023: Whole Body MRI and Liquid Biopsy Highlights & Side Effects. Trial Name: NCT05868486 — Phase < 1
Whole Body MRI and Liquid Biopsy 2023 Treatment Timeline for Medical Study. Trial Name: NCT05868486 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment for this trial still open?

"Yes, the details on clinicaltrials.gov illustrate that this study is currently enrolling participants. This trial was initially publicized on May 20th 2022 and recently updated on May 19th 2023. The project necessitates 100 volunteers to be sourced from one locale."

Answered by AI

How many individuals are registered to participate in this clinical study?

"Affirmative, data on clinicaltrials.gov indicates that this medical research initiative is still actively searching for participants. The trial was initially published on May 20th 2022 and the most recent update was made on May 19th 2023. Presently, they are in search of 100 patients from a single site to join their study."

Answered by AI
~4 spots leftby May 2024