MRI + Liquid Biopsy for Early Cancer Detection
Trial Summary
What is the purpose of this trial?
This study evaluates patient acceptability of whole body magnetic resonance imaging (WBM) and liquid biopsies (LB) in detecting early stage cancer in patients with a strong family history of cancer. Collecting family history and testing for genes passed on from parent to child (germline testing) can be used to predict the likelihood of a patient developing cancer. Currently, detection of early cancers focuses on screening specific organ systems such as breast and colon cancer. Magnetic resonance imaging (MRI) uses a large magnet and radio waves to look at organs and structures inside the body. Health care professionals use MRI scans to diagnose a variety of conditions, from torn ligaments to cancer. Liquid biopsy is test that analyzes blood samples to determine if cancer cells are present. This study may help researchers determine the feasibility of WBM and liquid biopsies to detect early stage cancer in patients that have a strong family history of cancer.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment MRI + Liquid Biopsy for Early Cancer Detection?
Is the combination of MRI and liquid biopsy safe for humans?
Liquid biopsies, which involve analyzing blood samples for cancer markers, are generally considered safe because they are minimally invasive, meaning they don't require surgery or other procedures that enter the body. MRI scans, especially those without contrast, are also widely used and considered safe for most people.12678
How does the MRI + Liquid Biopsy treatment for early cancer detection differ from other treatments?
Research Team
Dan Raz
Principal Investigator
City of Hope Medical Center
Eligibility Criteria
This trial is for adults with a strong family history of cancer, particularly those who are at least 50 years old or within 10 years of the age their relative was diagnosed with cancer. Participants must have multiple relatives with cancer and be willing to undergo genetic counseling, germline testing, and MRI scans without contrast. They should not have had any type of whole body imaging in the last three years or show signs/symptoms suggesting current cancer.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Testing
Participants undergo whole body MRI without contrast and blood sample collection for liquid biopsy. Germline testing may also be performed.
Follow-up
Participants are monitored for psychological distress and health-related quality of life up to 6 months after testing.
Treatment Details
Interventions
- Biospecimen Collection
- Genetic Testing for Cancer Risk
- Liquid Biopsy
- Magnetic Resonance Imaging of the Whole Body without Contrast
Find a Clinic Near You
Who Is Running the Clinical Trial?
City of Hope Medical Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator