← Back to Search

Other

MDMA for Social Behavior (MASM Trial)

Phase < 1
Waitlist Available
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up time frame: baseline-72 hours after completion of the sessions
Awards & highlights

MASM Trial Summary

This trial will study how MDMA (ecstasy) affects social motivation, ability, and function compared to a similar stimulant drug, in terms of brain activity.

Eligible Conditions
  • Social Behavior
  • Ecstasy
  • Stimulant Abuse
  • Motivation

MASM Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~time frame: baseline-72 hours after completion of the sessions
This trial's timeline: 3 weeks for screening, Varies for treatment, and time frame: baseline-72 hours after completion of the sessions for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Profile of Mood States

Side effects data

From 2018 Phase 1 & 2 trial • 12 Patients • NCT02876172
33%
Anxiety
17%
Nasal congestion
17%
Rash
17%
Dyspnoea
17%
Visual Impairment
17%
Vomiting
17%
Upper respiratory tract infection
17%
Arthropod bite
17%
Disturbance in attention
17%
Paresthesia
17%
Oropharyngeal pain
17%
Pruritis
17%
Dizziness
17%
Insomnia
17%
Rhinorrhoea
100%
80%
60%
40%
20%
0%
Study treatment Arm
CSO Patients Open-label CBCT and MDMA-assisted Therapy (up to 2 Months Post Last Experimental Dose)
CSO Patients at 6-month Follow-up
PTSD Patients at 6-month Follow-up
PTSD Patients Open-label CBCT and MDMA-assisted Therapy (up to 2 Months Post Last Experimental Dose)

MASM Trial Design

3Treatment groups
Experimental Treatment
Group I: Experimental: Placebo Then MDMA Then MethamphetamineExperimental Treatment3 Interventions
Participants first receive placebo at their first session in the laboratory. Then will return to the laboratory 5 days later and will receive 125 mg MDMA. Finally, 5 days later will return to the laboratory and will receive 20 mg of MA.
Group II: Experimental: Methampetamine Then Placebo Then MDMAExperimental Treatment3 Interventions
Participants first receive 20 mg of MA at their first session in the laboratory. Then will return to the laboratory 5 days later and will receive placebo. Finally, 5 days later will return to the laboratory and will receive 125 mg of MDMA.
Group III: Experimental: MDMA Then Placebo Then MethampetamineExperimental Treatment3 Interventions
Participants first receive 125 mg of MDMA at their first session in the laboratory. Then will return to the laboratory 5 days later and will receive placebo. Finally, 5 days later will return to the laboratory and will receive 20 mg of MA.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
MDMA
2001
Completed Phase 2
~390
Metamfetamine
FDA approved
placebo oral tablet
2021
Completed Early Phase 1
~80

Find a Location

Who is running the clinical trial?

University of ChicagoLead Sponsor
1,001 Previous Clinical Trials
817,687 Total Patients Enrolled
1 Trials studying Social Behavior
220 Patients Enrolled for Social Behavior

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it permissible to register seniors in this clinical experiment?

"According to the guidelines for this research, only individuals aged 18-40 may participate. In contrast, there are 7 and 18 trials respectively available for minors and seniors."

Answered by AI

Is this experiment recruiting participants presently?

"According to records on clinicaltrials.gov, this medical trial is presently attempting to enroll participants. The study was first announced on May 11th 2022 and its latest update was October 20th of the same year"

Answered by AI

How many participants are being monitored as part of this research endeavor?

"Affirmative, according to information posted on clinicaltrials.gov this trial is presently enrolling patients. The first posting was made on May 11th 2022 and the most recent update happened October 20th 2020, aiming to recruit 36 individuals from a single site."

Answered by AI

What are the requirements for participating in this clinical experiment?

"In order to partake in this medical trial, participants must be aged between 18 and 40 with healthy social behavior. 36 total individuals are needed for the study."

Answered by AI

Who else is applying?

What state do they live in?
Alabama
Florida
Other
California
How old are they?
65+
18 - 65
What site did they apply to?
University of Chicago
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
3+

Why did patients apply to this trial?

I have tried anti depressants to get me more social which didn’t work. I also have ptsd and have been wanting to do the mdma trials for social interaction. I have anti social disorder as well.
PatientReceived 1 prior treatment

How responsive is this trial?

Typically responds via
Email
Recent research and studies
clinicaltrials.govStudy
Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social Function
2022. "Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social Function". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05379959.
~15 spots leftby Apr 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top