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Alkalinizing Agent

Sodium Bicarbonate Tablets for Cognitive Impairment

Phase < 1
Waitlist Available
Research Sponsored by University of Colorado, Denver
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Able to provide consent
Age 50-75 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 12 months
Awards & highlights

Study Summary

This trial is testing whether sodium bicarbonate can improve cognitive and cerebrovascular function in patients with CKD stage 3b-4 who have metabolic acidosis.

Eligible Conditions
  • Cognitive Impairment
  • Metabolic Acidosis
  • Chronic Kidney Disease

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Cognitive Function at 12 months
Change in Cognitive Function composite score at 12 months
Change in Crystallized cognition composite score at 12 months
+1 more
Secondary outcome measures
Change in Cerebrovascular hemodynamics at 12 months

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Sodium bicarbonateExperimental Treatment1 Intervention
Sodium bicarbonate will be used at a dose of 0.5 mEq/kg-lean body weight/day.
Group II: PlaceboPlacebo Group1 Intervention
Placebo medication will be used at a dose of 0.5 mEq/kg-lean body weight/day

Find a Location

Who is running the clinical trial?

University of Colorado, DenverLead Sponsor
1,732 Previous Clinical Trials
2,143,514 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD
2021. "Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04600323.
~8 spots leftby Apr 2025
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